Bernhard Gerber: Myocardial Platelet Activation Linked to Microvascular Obstruction After STEMI
Bernhard Gerber, Editor in Chief European Heart Journal Cardiovascular Imaging at European Society of Cardiology, shared a post on LinkedIn about a recent article by Craig Balmforth et al., published in European Heart Journal, adding:
“EHJCVI Simultaneous publication presented at ESC congress 2026 in Munich
A fascinating study using 18F GP1 PET and CMR to investigate myocardial platelet activation and thrombosis in patients with microvascular obstruction (MVO) following STEMI.
MVO after STEMI was universally associated with myocardial platelet activation, extending beyond the structural abnormalities identified by cardiac MR.
These findings support an important mechanistic role of platelet mediated microvascular thrombosis in the development of no reflow and MVO, highlighting a potentially targetable biological pathway in a condition where effective therapies remain limited.
An exciting step toward better understanding the mechanisms underlying MVO and potentially identifying new therapeutic strategies for patients after STEMI.”
Title: Platelet activation and thrombosis in microvascular obstruction
Authors: Craig Balmforth , Alessandro Giaj Levra, Beth Whittington, Aidan Morgan, Mark G Macaskill, Evangelos Tzolos, Alex J Jordan, Tariq Ramtoola, Tim Clark, Michelle Rooney, Christophe Lucatelli, Edwin J R van Beek, Piotr J Slomka, Stephanie L Sellers, Norman Koglin, Andrew W Stephens, Iris Hardewig, David E Newby, Michelle C Williams, Marc R Dweck
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