Anand Padmanabhan: Persistence and Pathogenicity of Platelet Factor 4 Antibodies in VITT
Anand Padmanabhan, Professor and Clinician-Investigator at Mayo Clinic, shared a post on LinkedIn about a recent article he and his colleagues co-authored, adding:
“We are pleased to publish this paper on VITT as part of a multi-institutional effort.
Some key findings include:
- Rare patients may have antibodies with kappa light chains. This contrasts with current thinking that VITT antibodies can only include lambda light chains. More to come!
- While VITT anti-PF4 antibodies are clonally restricted, the monoclone/oligoclones are not evident upon study of the entire IgG repertoire, and require anti-PF4 antibody isolation to appreciate clonal restriction. This is in contrast to MGTS where a monoclonal antibody is clearly seen by SPEP/IFE/Mass-Fix.
- In one patient, we noted persisting platelet activating antibodies 4 yrs after the acute event, with chronic low-grade thrombocytopenia. Long-term follow up may be important in VITT!
Congrats to the entire team!”
Title: Platelet Factor 4 Antibody Persistence and Long-term Pathogenicity in Vaccine-induced Immune Thrombotic Thrombocytopenia
Authors: Adam Kanack, Emily Mauch, Guillaume Roberge, Noah Splinter, Krishna Gundabolu, Geoffrey D. Wool, Gemlyn George, Mouhamed Yazan Abou-Ismail, Kristi J. Smock, David L. Green, Jonathan Coker, Mindy C. Kohlhagen, David L. Murray, Anand Padmanabhan
Read the Full Article on JTH
More posts featuring Anand Padmanabhan on Hemostasis Today.
-
Apr 15, 2026, 17:01Emmanuel J Favaloro: Understanding Inherited and Acquired Coagulation Disorders
-
Apr 15, 2026, 16:55Chokri Ben Lamine: VA-ECMO vs VV-ECMO Thromboembolic Events – Key Clinical Pearls
-
Apr 15, 2026, 16:54Augustina Isioma Ikusemoro: The Most Misunderstood Cause of a Prolonged APTT in the Laboratory
-
Apr 15, 2026, 16:53Sickle Cell Disease Care Varies by Region – ASH
-
Apr 15, 2026, 16:40Jorge Lima։ Understanding Recurrent Pregnancy Loss
-
Apr 15, 2026, 16:26Pregnancy-Induced Rise in FIX Activity – A Challenge to International Hemophilia Guidelines – JTH
-
Apr 15, 2026, 16:18Ken Checicki: How Restoring Blood Flow Can Solve Post – DVT Complications
-
Apr 15, 2026, 16:05Alisha Tuck: Navigating the First Trimester – Ultrasound and Anticoagulation Management
-
Apr 15, 2026, 15:59Filippo Cademartiri: Plaque Burden Is the Dominant Determinant of Long-Term Coronary Risk Beyond Stenosis