Estelle Carminita։ What If the Origin of Platelet Dysfunction Starts in the Bone Marrow
Estelle Carminita, Research Fellow at Boston Children’s Hospital, shared a post on LinkedIn about a recent article she and her colleagues co-authored, adding:
”I’m thrilled to share that our latest study has been published in Blood Advances Blood Journals Portfolio!
In patients with chronic kidney disease (CKD), the risk of thrombotic events is markedly increased; yet the mechanisms underlying platelet dysfunction remain incompletely understood. While platelet abnormalities in CKD have traditionally been attributed to circulating uremic toxins, we asked a different question:
What if the origin of platelet dysfunction starts in the bone marrow?
I’m incredibly grateful to my collaborators and mentors Joseph Italiano, Kellie Machlus, Abolfazl Zarjou, who made this work possible.”
Title: Platelet dysfunction in chronic kidney disease arises from bone marrow remodeling and megakaryocyte reprogramming
Authors: Estelle Carminita, Virginia Camacho, Siobhan Branfield, Ethan Walsey, Maria N Barrachina, Dylan N Tabang, Dong H Lee, Isabelle C Becker, Sergey V Brodsky, Samer M Issa, Nicolas Gendron, Sarah Machado, Alisa S Wolberg, Hanno Steen, Bryce Kerlin, Kellie R Machlus, Abolfazl Zarjou, Joseph E Italiano
Read the Full Article on Blood Journals Portfolio.
Stay updated on all scientific advances with Hemostasis Today.
-
Sep 5, 2026, 19:20Yubrine Moraa Gachemba: BETULA Adds New Evidence for Catheter-Directed Thrombolysis in PE
-
Sep 5, 2026, 19:18John R. Mehall: The Importance of Anticoagulation Management in ECMO
-
Sep 5, 2026, 19:16Thirunavukkarasu Angappan: Why Hemophilia B Still Needs Both Plasma-Derived and Recombinant Factor IX
-
Sep 5, 2026, 19:15Michelle Leona Cecil: Comprehensive Hemophilia Care Doesn’t Begin and End With One Appointment
-
Sep 5, 2026, 19:13Amparo Santamaria: Stem Cells and Hematology – Unlocking a New Frontier in Ovarian Regeneration
-
Sep 5, 2026, 19:10Strengthening the Public Health System for Blood Disorders – Hemophilia Federation of America
-
Sep 5, 2026, 19:08Deidra D. Harris: Supporting Hemophilia of Georgia and the Bleeding Disorders Community
-
Sep 5, 2026, 19:06Katherine Blackwell: Blessed to Have the Opportunity to Speak at the Hemophilia of Indiana Annual Meeting
-
Sep 5, 2026, 19:04Christy V.: What You Need to Know about GI Bleeding and Hemophilia