Anand Padmanabhan: Persistence and Pathogenicity of Platelet Factor 4 Antibodies in VITT
Anand Padmanabhan, Professor and Clinician-Investigator at Mayo Clinic, shared a post on LinkedIn about a recent article he and his colleagues co-authored, adding:
“We are pleased to publish this paper on VITT as part of a multi-institutional effort.
Some key findings include:
- Rare patients may have antibodies with kappa light chains. This contrasts with current thinking that VITT antibodies can only include lambda light chains. More to come!
- While VITT anti-PF4 antibodies are clonally restricted, the monoclone/oligoclones are not evident upon study of the entire IgG repertoire, and require anti-PF4 antibody isolation to appreciate clonal restriction. This is in contrast to MGTS where a monoclonal antibody is clearly seen by SPEP/IFE/Mass-Fix.
- In one patient, we noted persisting platelet activating antibodies 4 yrs after the acute event, with chronic low-grade thrombocytopenia. Long-term follow up may be important in VITT!
Congrats to the entire team!”
Title: Platelet Factor 4 Antibody Persistence and Long-term Pathogenicity in Vaccine-induced Immune Thrombotic Thrombocytopenia
Authors: Adam Kanack, Emily Mauch, Guillaume Roberge, Noah Splinter, Krishna Gundabolu, Geoffrey D. Wool, Gemlyn George, Mouhamed Yazan Abou-Ismail, Kristi J. Smock, David L. Green, Jonathan Coker, Mindy C. Kohlhagen, David L. Murray, Anand Padmanabhan
Read the Full Article on JTH
More posts featuring Anand Padmanabhan on Hemostasis Today.
-
May 25, 2026, 14:58Samwel Mikaye: Pathophysiology, Clinical Features and Management of CAD
-
May 25, 2026, 14:57Rupam Manna: Approach and Management of Deep Vein Thrombosis in Cancer
-
May 25, 2026, 14:56Andrea Fischer: Celebrating Hematology Advocacy Recognition and New Achievements This Spring
-
May 25, 2026, 14:45Monica Schaller: How Do Autophagy, Inflammation, and NETs Interact to Drive Autoimmune Thrombosis?
-
May 25, 2026, 14:04Sophia Delicou: We Aim to Bridge Laboratory Insights and Clinical Practice for Unstable Hemoglobin Variants
-
May 25, 2026, 13:49Chaitanya Harita: Presenting AML Research at the British Society for Haematology Annual Scientific Meeting 2026
-
May 25, 2026, 13:04Mohammad Ameen Ishqair: Blood Group Antigens as Emerging Biomarkers in Disease
-
May 25, 2026, 13:04Dhruvi Joshi: Reduced-Dose DOAC Therapy in Patients With Venous Thromboembolism
-
May 25, 2026, 13:04Luke McLaughlin: Haemophilia Care as a Matter of Global Health Equity