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Annie Bauzon: Clinical Significance and Causes of RBC Anisocytosis
Annie Bauzon/LinkedIn
Jun 5, 2026, 18:38

Annie Bauzon: Clinical Significance and Causes of RBC Anisocytosis

Annie Bauzon, Medical Laboratory Assistant Technician at Med Health Laboratories, shared a post on LinkedIn:

“Anisocytosis of RBC

Anisocytosis refers to the presence of red blood cells (RBCs) of unequal sizes in a peripheral blood smear. It is commonly seen in various types of anemia and indicates abnormal erythropoiesis or RBC maturation.

Key Features:

  • Increased variation in RBC size.
  • Reflected by an increased RDW (Red Cell Distribution Width).
  • May show microcytes, macrocytes, or a mixed population of RBCs.
  • Best detected on a peripheral blood smear and automated hematology analyzers.

Common Causes:

  • Iron deficiency anemia
  • Megaloblastic anemia (Vitamin B12 and Folate deficiency)
  • Thalassemia
  • Hemolytic anemia
  • Liver disease
  • Myelodysplastic syndromes (MDS)
  • Post blood transfusion”

Pretty Annie Bauzon

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