Heparins Outperform DOACs and FXII/FXI Inhibitors in Preventing Thrombin Generation: JTH Study
Journal of Thrombosis and Haemostasis (JTH) shared an insightful post on LinkedIn:
“Effect of heparins, direct oral anticoagulants, and factor XII/factor XI inhibitors on catheter-initiated thrombin generation in platelet-rich plasma: an in vitro study
This in vitro catheter-initiated thrombin generation model compared heparins, DOACs, and emerging FXII/FXI inhibitors. Heparins were the most effective, with UFH completely suppressing thrombin generation at clinically relevant concentrations. DOACs and fondaparinux showed limited efficacy, while FXII/FXI inhibitors (asundexian, milvexian, garadacimab, abelacimab) did not adequately prevent coagulation on artificial surfaces. Results align with clinical observations, reinforcing UFH as the gold standard in invasive endovascular procedures.”
Read the full article here:
Article: Effect of heparins, direct oral anticoagulants, and factor XII/factor XI inhibitors on catheter-initiated thrombin generation in platelet-rich plasma: an in vitro study
Authors: Michael Hardy, Henri Thonon, Jonathan Douxfils, Julie Vassart, Isabelle Gouin–Thibault, Sarah Lessire, Thomas Lecompte, Francois
Stay updated with Hemostasis Today.
-
Sep 2, 2025, 13:59No Added Benefit of Surgery Within 72 Hours for Intracerebral Hemorrhage
-
Sep 2, 2025, 13:57DCB Technical Mastery Webinar by SCAI: European Best Practices for Complex Coronary Lesions
-
Sep 2, 2025, 13:51Zack Wheeler’s DVT Diagnosis Highlights Thoracic Outlet Syndrome Risks in Athletes: National Blood Clot Alliance
-
Sep 2, 2025, 13:39Heparins Outperform DOACs and FXII/FXI Inhibitors in Preventing Thrombin Generation: JTH Study
-
Sep 2, 2025, 08:51Perioperative Direct Oral Anticoagulant (DOAC) Dosing: Insights Dr. Sthanu Subramanian
-
Sep 3, 2025, 14:17Ron Blankstein Unlocks the Secrets to Healthy Vascular Aging and Atherosclerosis Imaging
-
Sep 3, 2025, 14:13Pulmonary Thromboembolism Explained: From Virchow’s Triad to Imaging, Treatment, and Complications
-
Sep 3, 2025, 12:48Richa Sharma Shares ARCADIA Post-Hoc Findings: Apixaban Prevents Recurrent Stroke in ESUS Patients with LV Dysfunction
-
Sep 2, 2025, 13:55Nirav Dhanesha and LSU Health Shreveport Team Discover Neutrophil Integrin α9 as a Key Target in Subarachnoid Hemorrhage Recovery
-
Sep 2, 2025, 13:42Torsten Tonn Highlights Breakthrough in Blood Pharming: miRNA-30a-5p Knockout Restores Red Cell Differentiation
-
Sep 2, 2025, 13:53Cost-Effective Strategies to Reduce Anaemia Highlighted in The Lancet Haematology
-
Sep 2, 2025, 13:04Ischemic Stroke or TIA Linked to Higher Femoral Fracture Risk
-
Sep 2, 2025, 12:51Treatment of Deep Brain AVMs Tied to Increased Hemorrhagic Stroke Risk
-
Aug 29, 2025, 09:03Vasculearn Network: New 2025 High Blood Pressure Guidelines Are Here
-
Aug 18, 2025, 23:56Dr. Arun V. J Invites You to His Lecture on ‘AI and Data Sciences in Transfusion Medicine’ at the AI in Healthcare Conclave. Register now!
-
Sep 3, 2025, 14:18Living with Factor V Deficiency: Helen’s Inspiring Story on Haemnet Haemcast
-
Sep 3, 2025, 14:11Leukoreduction Filters in Transfusion Medicine: 4 Factors That Matter Most
-
Sep 3, 2025, 14:00Jacek Lesinski: The Importance of Whole Blood and Plasma Donation
-
Sep 2, 2025, 14:02King Felipe VI Highlights Global Challenge of Cardiovascular Health at ESC Congress 2025
-
Sep 1, 2025, 08:09Wafik S. El-Deiry Opens Up on Recovery, Gratitude, and Book After Life-Changing Heart Surgery