Katie Harris and Colleagues: Coagulation Factors VIII and IX as Predictors of Cardiovascular Events and Mortality
Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn:
“Coagulation factors VIII and IX as predictors of cardiovascular events and mortality
By Katie Harris, Mark Woodward, Aaron Folsom, Pamela Lutsey, Ethan Cannon, Neil A Zakai, Mary Cushman, Nels C. Olson, Nithya Kannan, Ryan Packer, Katherine Wilkinson, Sasiwarang Goya Wannamethee, Christopher C. Patterson, Yoav Ben-Shlomo, and Gordon Lowe
Elevated coagulation factor levels are increasingly recognized as markers of vascular risk, yet their independent contribution to cardiovascular disease (CVD) outcomes remains debated.
In this meta-analysis (32,123 participants; 8,888 CVD cases), each SD increase in FVIII was associated with a 12% higher CVD risk and 16–17% higher CVD and all-cause mortality. FIX showed weaker associations—linked to mortality but not incident CVD.
Title: Associations between plasma levels of coagulation factors VIII and IX and incident cardiovascular disease and mortality: systematic review and meta-analysis
Authors: Katie Harris, Mark Woodward, Aaron R. Folsom, Pamela L. Lutsey, Ethan Cannon, Neil A. Zakai, Mary Cushman, Nels C. Olson, Nithya Kannan, Ryan Packer, Katherine Wilkinson, S. Goya Wannamethee, Christopher C. Patterson, Yoav Ben-Shlomo, Gordon D.O. Lowe
Read the article here.”
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