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Katie Harris and Colleagues: Coagulation Factors VIII and IX as Predictors of Cardiovascular Events and Mortality
Katie Harris/X
Nov 28, 2025, 16:41

Katie Harris and Colleagues: Coagulation Factors VIII and IX as Predictors of Cardiovascular Events and Mortality

Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn:

“Coagulation factors VIII and IX as predictors of cardiovascular events and mortality

By Katie Harris, Mark Woodward, Aaron Folsom, Pamela Lutsey, Ethan Cannon, Neil A Zakai, Mary Cushman, Nels C. Olson, Nithya Kannan, Ryan Packer, Katherine Wilkinson, Sasiwarang Goya Wannamethee, Christopher C. Patterson, Yoav Ben-Shlomo, and Gordon Lowe

Elevated coagulation factor levels are increasingly recognized as markers of vascular risk, yet their independent contribution to cardiovascular disease (CVD) outcomes remains debated.

In this meta-analysis (32,123 participants; 8,888 CVD cases), each SD increase in FVIII was associated with a 12% higher CVD risk and 16–17% higher CVD and all-cause mortality. FIX showed weaker associations—linked to mortality but not incident CVD.

Title: Associations between plasma levels of coagulation factors VIII and IX and incident cardiovascular disease and mortality: systematic review and meta-analysis

Authors: Katie Harris, Mark Woodward, Aaron R. Folsom, Pamela L. Lutsey, Ethan Cannon, Neil A. Zakai, Mary Cushman, Nels C. Olson, Nithya Kannan, Ryan Packer, Katherine Wilkinson, S. Goya Wannamethee, Christopher C. Patterson, Yoav Ben-Shlomo, Gordon D.O. Lowe

Katie Harris and Colleagues: Coagulation Factors VIII and IX as Predictors of Cardiovascular Events and Mortality

Read the article here.”

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Aaron Folsom cardiovascular disease (CVD) Christopher C. Patterson Ethan Cannon Factor IX Factor VIII Gordon Lowe Headlines Health Hematology Hemostasis Hemostasis Today Journal of Thrombosis and Haemostasis (JTH) Katherine Wilkinson Katie Harris Mark Woodward Mary Cushman Medicine Neil A. Zakai Nels C. Olson Nithya Kannan Pamela Lutsey Ryan Packer Sasiwarang Goya Wannamethee Yoav Ben-Shlomo
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