TNF-α–Mediated Platelet Dysfunction: Inflammation, Autophagy Inhibition, and Thrombosis Risk
Journal of Clinical Investigation (JCI), shared a post on X:
“ICYMI: How does inflammation drive platelet dysfunction and thrombosis across conditions?
Guadalupe Rojas-Sanchez, Pavel Davizon-Castillo and team reveals TNF-α–Syn17 signaling underlies impaired autophagy and mitochondrial dynamics in inflammation-associated thrombosis and hemorrhage.”
Read the full article here.
Title: TNF-α impairs platelet function by inhibiting autophagy and disrupting metabolism via syntaxin 17 downregulation
Authors: Guadalupe Rojas-Sanchez, Jorge Calzada-Martinez, Brandon McMahon, Aaron C. Petrey, Gabriela Dveksler, Gerardo P. Espino-Solis, Orlando Esparza, Giovanny Hernandez, Dennis Le, Eric P. Wartchow, Ken Jones, Lucas H. Ting, Catherine Jankowski, Marguerite R. Kelher, Marilyn Manco-Johnson, Marie L. Feser, Kevin D. Deane, Travis Nemkov, Angelo D’Alessandro, Andrew Thorburn, Paola Maycotte, José A. López, and Pavel Davizon-Castillo
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