Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
July, 2026
July 2026
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
Bethany Brown: There Is A Need for A Validated Replacement for The Discontinued 2,3-DPG Assay
Bethany Brown/LinkedIn
Feb 25, 2026, 12:30

Bethany Brown: There Is A Need for A Validated Replacement for The Discontinued 2,3-DPG Assay

Bethany Brown, Senior Director of Transfusion Innovation and Product Development at American Red Cross, reposted from ISBT on LinkedIn about a recent article she and her colleagues co-authored, adding:

”This paper discusses the need for a validated replacement for the discontinued 2,3-DPG assay.

It also demonstrates that neither p50 or ATP reliably predict red blood cell in vivo performance, highlighting the gap in tools for fully assessing the quality of emerging red blood cell products.”

Quoting International Society of Blood Transfusion (ISBT)‘s post:

”New in Vox Sanguinis: A BEST Collaborative study reviews red blood cell (RBC) quality assessment methods.

Findings highlight:

  • 2,3-DPG and P50 are not consistently correlated.
  • In vitro markers like ATP provide functional insight but show weak links to in vivo RBC kinetics.
  • A validated 2,3-DPG assay is essential for advancing blood product research and development.”

Title: Assessing red blood cell product quality with 2,3-DPG, ATP and p50 assays: A BEST Collaborative study

Authors: Tamar P. Feldman, Mackenzie Brandon-Coatham, Jayme Kurach, Carly Olafson, Jason Acker, Michael Wellington, Bethany L. Brown

Read the Full Article on Vox Sanguinis

Bethany Brown: There Is A Need for A Validated Replacement for The Discontinued 2,3-DPG Assay

Stay updated on all scientific advances with Hemostasis Today.

ATP Bethany Brown Bethany L. Brown Carly Olafson DPG Health Hematology Hemostasis Hemostasis News Hemostasis Today ISBT Jason Acker Jayme Kurach Mackenzie Brandon-Coatham Medicine Michael Wellington RBC Tamar P. Feldman Vox Sanguinis
NewsFeed