Bethany Brown: There Is A Need for A Validated Replacement for The Discontinued 2,3-DPG Assay
Bethany Brown, Senior Director of Transfusion Innovation and Product Development at American Red Cross, reposted from ISBT on LinkedIn about a recent article she and her colleagues co-authored, adding:
”This paper discusses the need for a validated replacement for the discontinued 2,3-DPG assay.
It also demonstrates that neither p50 or ATP reliably predict red blood cell in vivo performance, highlighting the gap in tools for fully assessing the quality of emerging red blood cell products.”
Quoting International Society of Blood Transfusion (ISBT)‘s post:
”New in Vox Sanguinis: A BEST Collaborative study reviews red blood cell (RBC) quality assessment methods.
Findings highlight:
- 2,3-DPG and P50 are not consistently correlated.
- In vitro markers like ATP provide functional insight but show weak links to in vivo RBC kinetics.
- A validated 2,3-DPG assay is essential for advancing blood product research and development.”
Title: Assessing red blood cell product quality with 2,3-DPG, ATP and p50 assays: A BEST Collaborative study
Authors: Tamar P. Feldman, Mackenzie Brandon-Coatham, Jayme Kurach, Carly Olafson, Jason Acker, Michael Wellington, Bethany L. Brown
Read the Full Article on Vox Sanguinis
Stay updated on all scientific advances with Hemostasis Today.
-
Aug 26, 2026, 13:05Preventing Thrombosis with WTDay26
-
Aug 26, 2026, 10:09Gemma Figtree: How Well Do We Predict Heart Attack Risk in Women?
-
Aug 26, 2026, 10:06Understanding and Managing Fatigue in ITP – ITP Support Association
-
Aug 26, 2026, 10:04Abdul Muqtadir Abbasi: When a High INR Hides a Thrombotic Cancer
-
Aug 26, 2026, 09:42Mohammed Alo: What’s Wrong With the New Blood Pressure Guidelines?
-
Aug 26, 2026, 09:01Mary Cushman: The Role of IL-6 in Cardiovascular Disease
-
Aug 26, 2026, 07:49Linda Koch: Understanding Ageing Through Biological Transitions
-
Aug 26, 2026, 05:38Elias Lee։ Beyond MCA Stenosis – Recognizing Moyamoya
-
Aug 26, 2026, 03:46Hugo Ribeiro: Which NSAIDs Are Safest for Older Adults?