Bethany Brown: There Is A Need for A Validated Replacement for The Discontinued 2,3-DPG Assay
Bethany Brown, Senior Director of Transfusion Innovation and Product Development at American Red Cross, reposted from ISBT on LinkedIn about a recent article she and her colleagues co-authored, adding:
”This paper discusses the need for a validated replacement for the discontinued 2,3-DPG assay.
It also demonstrates that neither p50 or ATP reliably predict red blood cell in vivo performance, highlighting the gap in tools for fully assessing the quality of emerging red blood cell products.”
Quoting International Society of Blood Transfusion (ISBT)‘s post:
”New in Vox Sanguinis: A BEST Collaborative study reviews red blood cell (RBC) quality assessment methods.
Findings highlight:
- 2,3-DPG and P50 are not consistently correlated.
- In vitro markers like ATP provide functional insight but show weak links to in vivo RBC kinetics.
- A validated 2,3-DPG assay is essential for advancing blood product research and development.”
Title: Assessing red blood cell product quality with 2,3-DPG, ATP and p50 assays: A BEST Collaborative study
Authors: Tamar P. Feldman, Mackenzie Brandon-Coatham, Jayme Kurach, Carly Olafson, Jason Acker, Michael Wellington, Bethany L. Brown
Read the Full Article on Vox Sanguinis
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