Brooke Wolford Leads Groundbreaking GWAS Study Identifying Novel Genetic Loci for Venous Thromboembolism
Brooke Wolford, Statistical Geneticist at NTNU, posted on LinkedIn:
”I’m excited to *finally* share my recent article in Blood Advances, “Multi-population GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.” Special thanks to Ida Surakka, Jordan Shavit, and Cristen Willer for supervision throughout the project.
During the first iteration of the Global Biobank Meta-analysis (led by Wei Zhou) we took a deep-dive into the VTE GWAS results to prioritize causal genes at the 38 significant loci using integrative bioinformatic gene prioritization.
Our wonderful colleagues in the Shavit lab, especially Queena Zhao, performed functional confirmatory laser-mediated endothelial injury to induce thrombosis in zebrafish after CRISPR/Cas9 knockdown of 6 genes. This provided supportive evidence for the role of RASIP1 and TC2N in the modification of human VTE.
Read more here.”
Title: Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish
Authors: Brooke N. Wolford, Queena Yakun Zhao, Kuan-Han H. Wu, Xinge Yu, Catherine E. Richter, Laxmi Bhatta, Ben M. Brumpton, Karl C. Desch, Florian Thibord, Derek Klarin, Andrew D. Johnson, David-Alexandre Trégouët, Scott M. Damrauer, Nicholas L. Smith, INVENT, MVP, Valeria Lo Faro, Kristin Tsuo, Global Biobank Meta-analysis Initiative (GBMI), Mark J. Daly, Benjamin M. Neale, Wei Zhou, Cristen J. Willer, Jordan A. Shavit, Ida Surakka
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