Brooke Wolford Leads Groundbreaking GWAS Study Identifying Novel Genetic Loci for Venous Thromboembolism
Brooke Wolford, Statistical Geneticist at NTNU, posted on LinkedIn:
”I’m excited to *finally* share my recent article in Blood Advances, “Multi-population GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish.” Special thanks to Ida Surakka, Jordan Shavit, and Cristen Willer for supervision throughout the project.
During the first iteration of the Global Biobank Meta-analysis (led by Wei Zhou) we took a deep-dive into the VTE GWAS results to prioritize causal genes at the 38 significant loci using integrative bioinformatic gene prioritization.
Our wonderful colleagues in the Shavit lab, especially Queena Zhao, performed functional confirmatory laser-mediated endothelial injury to induce thrombosis in zebrafish after CRISPR/Cas9 knockdown of 6 genes. This provided supportive evidence for the role of RASIP1 and TC2N in the modification of human VTE.
Read more here.”
Title: Multipopulation GWAS for venous thromboembolism identifies novel loci followed by experimental validation in zebrafish
Authors: Brooke N. Wolford, Queena Yakun Zhao, Kuan-Han H. Wu, Xinge Yu, Catherine E. Richter, Laxmi Bhatta, Ben M. Brumpton, Karl C. Desch, Florian Thibord, Derek Klarin, Andrew D. Johnson, David-Alexandre Trégouët, Scott M. Damrauer, Nicholas L. Smith, INVENT, MVP, Valeria Lo Faro, Kristin Tsuo, Global Biobank Meta-analysis Initiative (GBMI), Mark J. Daly, Benjamin M. Neale, Wei Zhou, Cristen J. Willer, Jordan A. Shavit, Ida Surakka
Stay updated with Hemostasis Today.
-
Feb 23, 2026, 18:13Fight4Hematology Supports Research and Empowers the Next Generation – ASH
-
Feb 23, 2026, 17:59Wolfgang Miesbach: Real-World Evidence of Emicizumab on Joint Outcomes in Hemophilia A
-
Feb 23, 2026, 17:56Shiny K Kajal: The Transfusion Reaction We Often Miss
-
Feb 23, 2026, 17:53Radheshyam Meher: Contributing to the Transfusion Evidence Round-Up for International Childhood Cancer Day 2026
-
Feb 23, 2026, 17:46Mahesan Subramaniam: The Physiological Impact of Anger on Immunity
-
Feb 23, 2026, 17:42Bryan Fry: First Evidence That Bothrops atrox Venom Directly Activates Human Factor VII
-
Feb 23, 2026, 17:34Bastu Odoka: Why Blood Should NOT be Left at the Bedside to ‘Warm’
-
Feb 23, 2026, 17:28Henry Burkitt: Patients Are Challenging How the Medicines Policy System Works in England
-
Feb 23, 2026, 16:50Mutaz Al‑Sabah: Interesting Webinar on FH in Women is Now Available to Watch