Domenico Simone Castiello: Rethinking Prolonged DAPT in Multivessel PCI – Insights from the DAPT-MVD Trial
Domenico Simone Castiello, Graduate Research Fellow at Cardialysis, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in NEJM, adding:
“Just published in the New England Journal of Medicine! NEJM Group
How long should dual antiplatelet therapy (DAPT) be continued after percutaneous coronary intervention (PCI)?
Despite decades of research, finding the optimal balance between ischemic protection and bleeding risk remains one of the most relevant challenges in interventional cardiology.
The recently published DAPT-MVD trial (https://lnkd.in/eWmurJfv) in the New England Journal of Medicine NEJM Group provides important new evidence, suggesting that prolonged DAPT may offer additional ischemic protection in selected patients with multivessel coronary artery disease, without a significant increase in bleeding events.
But how should these findings influence contemporary clinical practice?
And how far can we extend their implications to broader patient populations?
Together with Dr. Ernest Spitzer I am pleased to share our recently published Letter to the Editor in the New England Journal of Medicine NEJM Group, contributing to the scientific discussion surrounding this important trial and the interpretation of its findings.
Read our correspondence here:
Where do we go from here?
Does DAPT-MVD make the case for prolonged DAPT, or is it time to rethink aspirin monotherapy as the comparator in future trials?
Your thoughts are welcome!”
Title: Extended Dual Antiplatelet Therapy for Multivessel Coronary Artery Disease
Authors: Jinwei Tian, Zhuozhong Wang, Yan Wang, Fan Wang, Xiang Peng, Jiandong Xiao, Chunjie Li, Xinyu Hou, Qian Tong, Xi Yu, Guangren Gao, Peng Zhao, Jie Zhao, Ying Liu, Zhexue Qin, Haijing Lu, Shujiang Zhang, Shengli Li, Zhiyuan Weng, Huifang Tang, Yuquan He, Chunpeng Zhang, Yong Liu, Jun Jiang, Jinying Zhang, Lei Cai, Lili Xiu, Gary S. Mintz, Duolao Wang, Gregg W. Stone, Bo Yu
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 20, 2026, 03:37Rucha Patil: Scaling POC Diagnostics for Haemophilia A and VWD Across India
-
Oct 20, 2026, 03:31Zena Vexler: Targeting Neutrophil Elastase and NETosis to Mitigate Infection-Triggered Childhood Stroke
-
Oct 20, 2026, 03:24Chaza Alaji: Diagnosing Protein C and Protein S Deficiency
-
Oct 20, 2026, 03:24Mou Nandi: How Maternal Health During Pregnancy May Shape Infant Development
-
Oct 20, 2026, 03:13Sumyea Kabir: Pre-Analytical Quality in Phlebotomy – Preventing In Vitro Hemolysis
-
Oct 20, 2026, 02:37M. Sekip Altunkan: Can Anticoagulation Be Safely Stopped After AF Ablation?
-
Oct 20, 2026, 02:26Ahmed Ammar: Managing VT Recurrence Post-Ablation
-
Oct 20, 2026, 01:43Oliver Weingärtner: Deprescribing of Lipid Lowering Drug after MI is Associated with Cardiovascular Events
-
Oct 19, 2026, 19:44Where You Live Should not Determine Whether You Receive Care – World Federation of Hemophilia