Juan Andrés De Pablo Moreno and Colleagues on Therapeutic FVIII Administration in Hemarthrosis in Mice
Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn:
”Defective lymphangiogenesis and iron removal after hemarthrosis in factor VIII–deficient mice are rectified with therapeutic factor VIII administration — implications for joint health
By Bilgimol Chumappumkal Joseph, Juan Andrés De Pablo Moreno, Nicca Falah, Mia Lora Cacho, and Annette von Drygalski
Recurrent joint bleeding in hemophilia leads to iron deposition, impaired lymphangiogenesis, and progressive arthropathy.
In a murine model of factor VIII deficiency, researchers compared saline, short-course recombinant FVIII, and prolonged murine Fc-FVIII therapy following induced knee hemarthrosis.
Sustained FVIII activity (~30–40%) enabled normal lymphangiogenesis, rapid iron clearance, and cartilage recovery, whereas short or absent replacement resulted in synovial iron overload and poor repair.”
Read the full article in JTH.
Article: Defective lymphangiogenesis and iron removal after hemarthrosis in factor VIII-deficient mice are rectified with therapeutic factor VIII administration—implications for joint health
Authors: Bilgimol Chumappumkal Joseph, Juan Andrés De Pablo Moreno, Nicca Falah, Mia Lora Cacho, Annette von Drygalski
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