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Ivo Francischetti and Colleagues on Glycoprotein VI Contributing to Platelet Activation in HIT
Ivo Francischetti/John Hopkins Medicine
Oct 11, 2025, 08:34

Ivo Francischetti and Colleagues on Glycoprotein VI Contributing to Platelet Activation in HIT

Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn:

”Glycoprotein VI is a receptor for the PF4/anti-PF4 IgG complex and contributes to platelet activation in heparin-induced thrombocytopenia (HIT)

By Ivo Francischetti, Kathryn Dane, Ed Galgo, Michael B. Streiff, and John F. Andersen

Heparin-induced thrombocytopenia (HIT) involves platelet activation by PF4/anti-PF4 complexes.

This study identifies glycoprotein VI (GPVI) as a receptor for these complexes, enhancing PF4 binding (Kd ≈ 30–100 nM) and platelet aggregation via FcγRIIA.

GPVI blockade (anti-GPVI antibodies, ACT017) suppressed activation, while AlphaFold modeling revealed electrostatic interactions between GPVI and PF4/IgG.

These findings position GPVI as a potential therapeutic target in HIT.”

Read the full article in JTH.

Article: Glycoprotein VI is a receptor for the PF4/anti-PF4 IgG complex and contributes to platelet activation in heparin-induced thrombocytopenia (HIT)

Authors: Ivo Francischetti, Kathryn Dane, Ed Galgo, Michael Streiff, John Andersen

Ivo Francischetti and Colleagues on Glycoprotein VI Contributing to Platelet Activation in HIT

Stay updated on all scientific advances with Hemostasis Today.

Ed Galgo Glycoprotein VI Health Hematology Hemostasis Hemostasis Today Heparin HIT Ivo Francischetti John Andersen Kathryn Dane Medicine Michael Streiff thrombosis
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