Ivo Francischetti and Colleagues on Glycoprotein VI Contributing to Platelet Activation in HIT
Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn:
”Glycoprotein VI is a receptor for the PF4/anti-PF4 IgG complex and contributes to platelet activation in heparin-induced thrombocytopenia (HIT)
By Ivo Francischetti, Kathryn Dane, Ed Galgo, Michael B. Streiff, and John F. Andersen
Heparin-induced thrombocytopenia (HIT) involves platelet activation by PF4/anti-PF4 complexes.
This study identifies glycoprotein VI (GPVI) as a receptor for these complexes, enhancing PF4 binding (Kd ≈ 30–100 nM) and platelet aggregation via FcγRIIA.
GPVI blockade (anti-GPVI antibodies, ACT017) suppressed activation, while AlphaFold modeling revealed electrostatic interactions between GPVI and PF4/IgG.
These findings position GPVI as a potential therapeutic target in HIT.”
Read the full article in JTH.
Article: Glycoprotein VI is a receptor for the PF4/anti-PF4 IgG complex and contributes to platelet activation in heparin-induced thrombocytopenia (HIT)
Authors: Ivo Francischetti, Kathryn Dane, Ed Galgo, Michael Streiff, John Andersen
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