Jiri Damborsky and Team: Thrombolytic Proteins Profiling: High-Throughput Activity, Selectivity, And Resistance Assays
Jiri Damborsky, Head of Research Group at ICRC, Loschmidt Laboratories and Masaryk University, posted on LinkedIn:
”STROKE – Thrombolytic proteins profiling: High-throughput activity, selectivity, and resistance assays
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop
Published: October 4, 2025, FEBS Open Bio.
Read here.
We introduce optimized high-throughput assays for rapid and reliable screening of thrombolytic enzymes – enabling detailed insights into activity, fibrin selectivity, and inhibition resistance.
Cardiovascular and thrombotic diseases remain one of the world’s top health challenges. In our latest work, we introduce a comprehensive set of high-throughput biochemical assays that enable robust screening and detailed characterization of thrombolytic biomolecules – including activity, fibrin selectivity, clot binding, and inhibition resistance.
Using alteplase and tenecteplase as model enzymes, we demonstrate how these assays can accelerate the development of safer and more effective thrombolytic drugs. Our results confirm that tenecteplase outperforms alteplase in fibrin selectivity and inhibition resistance, supporting its growing clinical relevance.”
Title: Thrombolytic proteins profiling: High-throughput activity, selectivity, and resistance assays
Authors: Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop
Stay informed with Hemostasis Today.
-
Oct 16, 2026, 06:17Neha Rastogi Panda: Precision Diagnosis and Organ Preservation in Splenic Abscess
-
Oct 16, 2026, 05:53Alejandro González Veliz: Looking Beyond Coronary Anatomy to Understand Ischemia
-
Oct 16, 2026, 04:16Asmaa M. Gouda: Advancing Blood Bank Leadership at Alexandria University Hospitals
-
Oct 16, 2026, 03:52Saja Al-Zamili: Minimally Invasive Hematoma Evacuation in Intracerebral Hemorrhage
-
Oct 16, 2026, 03:13Bhumika Satija: Beyond the Diploma A Growing Passion for Blood Banking and Transfusion Medicine
-
Oct 16, 2026, 03:03Jamie Nash: Microfluidics in Transfusion Medicine Advancing Blood Component Quality Assessment
-
Oct 16, 2026, 02:53World Thrombosis Day 2026 Advancing Women’s Health Through Better Thrombosis Research and Care – World Thrombosis Day
-
Oct 16, 2026, 02:42Areej Wasi: Myocardial Infarction in Young Adults Advancing Cardiology Education and Medical Leadership
-
Oct 16, 2026, 02:33Mehak Trehan: ASH 2026 Myelofibrosis Guidelines 10 Practical Takeaways for Clinical Practice