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Joseph Italiano: Exploring the Intersection of Megakaryocyte Biology and Chronic Kidney Disease
Estelle Carminita/researchgate.net; Joseph Italiano/stellularbio.com
Mar 2, 2026, 15:08

Joseph Italiano: Exploring the Intersection of Megakaryocyte Biology and Chronic Kidney Disease

Joseph Italiano, Associate Professor of Medicine of Harvard University and Co-founder of Platelet BioGenesis, shared a post on LinkedIn about recent article he and his colleagues co-authored:

“I’m excited to share our latest study, published in Blood Advances and led by Estelle Carminita, exploring the intersection of megakaryocyte biology and chronic kidney disease.

In this work, we demonstrate that chronic kidney disease reprograms megakaryocytes, driving the production of dysfunctional platelets.

We’re deeply grateful to our outstanding collaborators whose expertise and dedication made this work possible.”

Title: Platelet dysfunction in chronic kidney disease arises from bone marrow remodeling and megakaryocyte reprogramming

Authors: Estelle Carminita, Virginia Camacho, Siobhan Branfield, Ethan Walsey, Maria N. Barrachina, Dylan N. Tabang, Dong H. Lee, Isabelle C. Becker, Sergey V. Brodsky, Samer M. Issa, Nicolas Gendron, Sarah Machado, Alisa S. Wolberg, Hanno Steen, Bryce Kerlin, Kellie R. Machlus, Abolfazl Zarjou, Joseph E. Italiano

Read the Full Article on Blood Advances.

Platelet dysfunction in chronic kidney disease arises from bone marrow remodeling and megakaryocyte reprogramming

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Abolfazl Zarjou Alisa S. Wolberg Blood Advances Bryce Kerlin chronic kidney disease (CKD) Dong H. Lee Dylan N. Tabang Estelle Carminita Ethan Walsey Hanno Steen Harvard University Headlines Health Hematology Hemostasis Hemostasis News Hemostasis Today Isabelle C. Becker Joseph E. Italiano Joseph Italiano Kellie R. Machlus Maria N. Barrachina Medicine Nicolas Gendron Platelet BioGenesis Platelet dysfunction Samer M Issa Sarah Machado Sergey V. Brodsky Siobhan Branfield Virginia Camacho
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