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JTH: New Data Exposes Wide Variation in U.S. Perioperative Bleeding Management
Roman Sniecinski/LinkedIn
Nov 19, 2025, 13:33

JTH: New Data Exposes Wide Variation in U.S. Perioperative Bleeding Management

Journal of Thrombosis and Haemostasis (JTH) posted on LinkedIn:

”Perioperative use of factor concentrates and blood products – a survey of clinical practices in the United States

By Jerrold Levy, Joseph R. Shaw, Kamrouz Ghadimi, Cheryl Maier, Douketis James, Keyvan Karkouti, Michael Mazzeffi, Alex C Spyropoulos, MD, FACP, FCCP, FRCPC, Kenichi Tanaka, Jean Connors, and Roman Sniecinski

The management of perioperative bleeding and anticoagulant reversal is rapidly evolving, shaped by new education initiatives and expanding availability of factor concentrates.

4-factor PCCs were the preferred therapy for warfarin and DOAC reversal in emergency surgery and major bleeding (used by >70%).

Cryoprecipitate remained the dominant source of fibrinogen replacement (66%), while access to fibrinogen concentrate was limited.

FFP continued as the first-line product for factor replacement in cardiac (60%), hepatic (67%), and postpartum hemorrhage (71%).

These data show a steady shift toward PCC-centric reversal strategies, with persistent heterogeneity in fibrinogen replacement and factor support across US perioperative settings.

Read the article here.”

Title: Perioperative use of factor concentrates and blood products—a survey of clinical practices in the United States: communication from the ISTH Subcommittee on Perioperative and Critical Care

Authors: Jerrold H. Levy, Joseph R. Shaw, Kamrouz Ghadimi, Cheryl L. Maier, James Douketis, Keyvan Karkouti, Michael Mazzeffi, Alex C. Spyropoulos, Kenichi A. Tanaka, Jean M. Connors, Roman M. Sniecinski

JTH

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Alex C. Spyropoulos Bleeding management Cheryl L. Maier Health Hematology Hemostasis Hemostasis Today James Douketis Jean M. Connors Jerrold H. Levy Joseph R. Shaw Journal of Thrombosis and Haemostasis JTH Kamrouz Ghadimi Kenichi A. Tanaka Keyvan Karkouti Medicine Michael Mazzeffi Perioperative Bleeding Roman M. Sniecinski thrombosis
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