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Leonardo Roever: Diagnosis and Management of Natural Anticoagulant Deficiencies
Leonardo Roever/LinkedIn
Aug 31, 2026, 14:12

Leonardo Roever: Diagnosis and Management of Natural Anticoagulant Deficiencies

Leonardo Roever, CEO of Brazilian Evidence-Based Health Network, shared a post on LinkedIn about a recent article by Katarzyna Mayger et al, published in Journal of Thrombosis and Haemostasis, adding:

“Physiological anticoagulant deficiencies: pathogenesis, diagnosis, and clinical implications

Physiological anticoagulants are essential regulators of coagulation; their deficiency shifts hemostasis toward a pro-thrombotic state, increasing the risk of venous thromboembolism.

The main physiological anticoagulants—antithrombin (AT), protein C (PC), and protein S (PS)—operate via distinct mechanisms: AT directly inhibits active proteases, primarily thrombin and factor Xa, while PC inactivates activated factors V and VIII, with PS acting as a cofactor.

Deficiencies can be hereditary (resulting from genetic mutations) or acquired (resulting from reduced synthesis or increased consumption).”

Title: Physiological anticoagulant deficiencies: pathogenesis, diagnosis, and clinical implications

Authors: Katarzyna Mayger, Christelle Orlando, Beverley J. Hunt

Leonardo Roever: Diagnosis and Management of Natural Anticoagulant Deficiencies

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