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Marc Carrier: Important New Data From the API-CAT Trial on Recurrent VTE During Extended Apixaban Therapy
Marc Carrier,Isabelle Mahé/LinkedIn
Jul 13, 2026, 15:42

Marc Carrier: Important New Data From the API-CAT Trial on Recurrent VTE During Extended Apixaban Therapy

Marc Carrier, Professor at Ottawa Hospital Research Institute, shared on LinkedIn about a recent article by Isabelle Mahé et al, published in Circulation, adding:

”Exciting results presented by Prof Isabelle Mahé at the International Society on Thrombosis and Haemostasis (ISTH) 2026 Congress in Paris, with simultaneous publication in Circulation.

Key findings from this pre-specified ancillary analysis of the API-CAT trial include:

  • Recurrent VTE during extended apixaban therapy was uncommon, occurring in only 2.5% of 1,766 patients over 12 months.
  • The risk of recurrence differed by cancer type, with the highest incidence observed in gastrointestinal cancers (excluding colorectal).
  • The index VTE strongly predicted the pattern of recurrence. Patients presenting initially with PE were most likely to recur with PE, while those with isolated DVT recurred exclusively with DVT.
  • Despite its low frequency, recurrent VTE carried a very poor short-term prognosis, with 50% mortality occurring within a median of just 24 days following recurrence.”

Title: Prognosis of Recurrent Venous Thromboembolism During Extended Apixaban Therapy for Cancer-Associated Thrombosis: Insights From the API-CAT Randomized Trial

Authors: Isabelle Mahé, Céline Chapelle, Marc Righini, Grégoire Le Gal, Frederikus A. Klok, Giancarlo Agnelli, Francis Cajfinger, Marie-Antoinette Sevestre, Philippe A. Grenier, Jérôme Alexandre, Francis Couturaud, Patrick Mismetti, Silvy Laporte, Jean Chidiac

Marc Carrier: Important New Data From the API-CAT Trial on Recurrent VTE During Extended Apixaban Therapy

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Celine Chapelle DVT Francis Cajfinger Francis Couturaud Frederikus A Klok Giancarlo Agnelli Gregoire Le Gal Health Hematology Hemostasis Hemostasis News Hemostasis Today Isabelle Mahé Jean Chidiac Jérôme Alexandre Marc Carrier Marc Righini Marie-Antoinette Sevestre Medicine Patrick Mismetti PE Philippe A. Grenier Pulmonary embolism Silvy Laporte thrombosis VTE
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