Marcin Kurzyna: New NEJM Trial Evaluates Catheter-Directed Thrombolysis in PE
Marcin Kurzyna, Chairman-Elect of Working Group on Pulmonary Circulation and Right Ventricular Function at European Society of Cardiology, shared a post on LinkedIn about a recent article by Josef Kroupa et al, published in The New England Journal of Medicine, adding:
“The next landmark trial in the field of interventional treatment of pulmonary embolism is coming from Czechia!
Catheter-directed thrombolysis (without ultrasound) versus anticoagulation alone in intermediate-high-risk PE with some additional ‘red flags’ in a prospective, multicenter, open-label trial.
Mortality/morbidity combined endpoint driven by clinical deterioration, without differences in mortality, but 4 deaths (1.4 percent) in the AC group versus 1 in the CDT group (0.36 percent, p=NS).
Two intracranial bleedings in CDT group versus none in AC (p=NS), but without increase of major bleeding in the CDT cohort.
No evidence for a more extensive reduction in the RV/LV ratio after 48 h in the CDT group.
Big kudos and congratulations to Josef Kroupa and the whole group!
Presented at ESC Congress and published simultaneously in NEJM.”
Title: Catheter-Directed Thrombolysis in Intermediate-High–Risk Pulmonary Embolism
Authors: Josef Kroupa, Martin Radvan, Jan Mrozek, Martin Sluka, Stepan Jirous, Ota Hlinomaz, Milan Pliva, Jan Pudil, Hana Voberkova, Karolina Bartoskova, Martin Poloczek, Martin Kamenik, Michal Brabec, Eva Lichnerova, Martin Hutyra, Ivo Bernat, Martin Novak, Johana Horakova, Lucie Jelinkova, Tomas Knize, Petr Tousek, Cyril Stechovsky, Filip Varhanik, Zdenek Coufal, Jiri Jarkovsky, Viktor Kocka
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