Markus Gregorio Barbosa: Hepatic VPS35 and Cholesterol Homeostasis
Markus Gregorio Barbosa, Former PhD Candidate at UMCG, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Molecular Metabolism, adding:
”Happy to share that our latest study is now published in Molecular Metabolism
Our findings reveal a novel role for hepatic VPS35 in cholesterol homeostasis, linking impaired lipoprotein uptake and lysosomal cholesterol metabolism to metabolic liver disease and atherosclerotic cardiovascular disease.
A great collaborative effort with Cristy Verzijl, Dyonne V., Bart van de Sluis, all the co-authors, and our collaborators at EndoConnect, Laboratory of Pediatrics, Beatrix Children’s Hospital UMCG NL and UMCG research. Thank you all for your contributions.”
Title: Hepatic retromer is essential for systemic cholesterol homeostasis by regulating lysosomal cholesterol handling
Authors: Cristy R.C. Verzijl, Markus G. Barbosa, Dyonne Y. Vos, Andries H. Heida, Amandine Caillaud, Lauri Vanharanta, Xiaoke Ge, Joël J. Tissink, Mirjam H. Koster, Marieke Smit, Nicolette Huijkman, Niels J. Kloosterhuis, Aurore Girardeau, Zoé Begué-Racapé, Vincent W. Bloks, Rick Havinga, Marceline M. Fuh, Fulvio Reggiori, Muriel Mari, Ludger Scheja, Bart van de Sluis
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