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Quintijn Bonnez: Detecting ADAMTS13 Structural Changes with Conformation-Sensitive Antibody 1C4
Quintijn Bonnez/KU Leuven; Karen Vanhoorelbeke/LinkedIn
Apr 9, 2026, 15:04

Quintijn Bonnez: Detecting ADAMTS13 Structural Changes with Conformation-Sensitive Antibody 1C4

Quintijn Bonnez, Early-Career Board Member at Belgian Society on Thrombosis and Haemostasis, shared on LinkedIn:

”New book chapter in Methods in Molecular Biology by Springer Nature.

We here describe how the conformation-sensitive Antibody 1C4 can be used to detect structure changes in ADAMTS13.

In closed ADAMTS13, the 1C4 epitope remains cryptic and only upon opening, potent 1C4 binding occurs.

Just a structural curiosity, or much more?

Over the last decade, we investigated the molecular mechanisms of ADAMTS13 conformation changes in Health and Disease.

Emerging as a powerful Biomarker, open ADAMTS13 supports the diagnosis of acute immune-mediated TTP and the prediction of early relapse risk.

Read all methodological details.

Interested in broader methodologies for ADAMTS and ADAMTS-like proteases?

Find the full book.”

Title: Determining ADAMTS13 Conformation for the Diagnosis of Immune Thrombotic Thrombocytopenic Purpura and Prediction of Relapse

Authors: Quintijn Bonnez, Karen Vanhoorelbeke

Read the Full Article on ADAMTS Proteases

Quintijn Bonnez: Detecting ADAMTS13 Structural Changes with Conformation-Sensitive Antibody 1C4

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1C4 ADAMTS Proteases ADAMTS13 bleeding disorders Health Hematology Hemostasis Hemostasis News Hemostasis Today Karen Vanhoorelbeke Medicine Methods in Molecular Biology Quintijn Bonnez Springer Nature
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