Ralf Ludwig։ Testing Human-Targeted Therapies in a Human Immune System
Ralf Ludwig, Director of the Lübeck Institute of Experimental Dermatology at the University of Lübeck, shared a post on LinkedIn:
”How do you test a human-targeted therapy on a human immune system — before the first patient?
In this study we used humanized immune system (HIS) mice: animals reconstituted with human blood cells, carrying human leukocytes and human Fcγ receptors.
We induced an EBA-like skin disease and treated with the BTK inhibitor ibrutinib — and disease was significantly reduced, driven by human cells.
The model itself was established by Anja Lux and colleagues within CRC 1526, and described here: ‘A human immune system mouse model for preclinical evaluation of therapies in pemphigoid disease‘(Voss et al.)
It’s the bridge most autoimmune research still lacks: a place to ask whether a therapy actually touches human immunity in vivo — not just mouse.
We used it to test the impact of kinase inhibitors on pemphigoid diseases.”
Title 1: Targeting neutrophil signaling networks in immune complex-mediated autoimmune disease
Authors: Mareile Schlotfeldt, Colin Osterloh, Anika Kasprick, Carla Zünkeler, Mikko Armbrust, Georg Kaiser, Katharina Schulze Dieckhoff, Thorge Mester, Pia Stüssel, Nancy Ernst, Ann-Kathrin Schneider, Leonie Voss, Adrian P. Mansini, Seyed Mohammad Vahabi, Yulu Wang, Haley Gainer, Jing Li, Gestur Vidarsson, Remco Visser, Frank Petersen, Xinhua Yu, Kyle T. Amber, Anja Lux, Ralf J. Ludwig, Katja Bieber
Title 2: A human immune system mouse model for preclinical evaluation of therapies in pemphigoid disease
Authors: Leonie Voss, Katharina Maier, Stella Wagner, Ann-Kathrin Schneider, Mareile Schlotfeldt, Leon Altmann, Emir Ucgan, Lukas Hönninger, Matthias Peipp, Falk Nimmerjahn, Katja Bieber, Anja Lux
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 19, 2026, 19:44Where You Live Should not Determine Whether You Receive Care – World Federation of Hemophilia
-
Oct 19, 2026, 19:42Belen Bianco: Prevention, Early Suspicion and an Interdisciplinary Approach Save Lives
-
Oct 19, 2026, 19:40Christina Chrysohoou: Catheter-Based LAAC vs OAC for Stroke Prevention in Atrial Fibrillation
-
Oct 19, 2026, 19:38Matthew Flick: A Two-Day Research Meeting on Fibrinogen, Hemostasis and Thrombosis
-
Oct 19, 2026, 19:37Hayat Saeed: Excited to Share Our Publication on the FGL1–Hepcidin Axis in Iron Homeostasis and Disease
-
Oct 19, 2026, 19:08IPAW 2026 Comes to a Close, but the Work Continues – PPTA
-
Oct 19, 2026, 17:44Paul Riley: Moderating a Webinar on Anticoagulation Monitoring
-
Oct 19, 2026, 16:36Christopher Pittman: Blood Clot Prevention Cannot End at Hospital Discharge
-
Oct 19, 2026, 16:13Javier M. Floren: When Immune Cells Move With Their Environment