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Raul Santos: International Collaborative Insights into the Treatment of Homozygous FH
Raul Santos/LinkedIn
Feb 19, 2026, 13:51

Raul Santos: International Collaborative Insights into the Treatment of Homozygous FH

Raul Santos, Researcher at ARO Hospital Israelita Albert Einstein, shared on LinkedIn about a recent article he and his colleagues co-authored, adding:

“The therapy of Homozygous FH (HoFH) is a great challenge due to the extreme elevated LDL-C levels and the genetic variability that characterizes this disease.

Combination therapy is the rule to reduce LDL-C, and is classified in medications that depend on the LDL receptor function like statins, ezetimibe and PCSK9 inhibitors and those who are independent like Lomitapide and Evinacumab.

In this collaborative study between Canada, South Africa and Brazil led by John Mancini we showed that statins also reduce LDL-C by mechanisms other than depending on the LDL receptor alone.

HoFH is a devastating disease that needs to be diagnosed and treated ASAP.

Novel therapies are coming and hopefully will change for good how we treat this disease!”

Article: Assessment of LDL receptor-dependent lipid lowering therapies in patients with homozygous familial hypercholesterolemia according to functional genotype.

Authors: G.B.John Mancini, Arnold Ryomoto, Isabelle Ruel, Iulia Iatan, Jacques Genest, Frederick J. Raal, Raul D. Santos, Ana Paula Marte, Brooke A. Kennedy, Liam R. Brunham, Daniel Gaudet, Miriam Larouche, Diane Brisson, Robert A. Hegele

Read the Full Article on Atherosclerosis

Raul Santos: International Collaborative Insights into the Treatment of Homozygous FH

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Ana Paula Marte Arnold Ryomoto Brooke A. Kennedy Daniel Gaudet Diane Brisson FH Frederick J. Raal G.B. John Mancini Health Hematology Hemostasis News Hemostasis Today Isabelle Ruel Iulia Iatan Jacques Genest Liam R. Brunham Medicine Miriam Larouche Raul D. Santos Raul Santos Robert A. Hegele
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