Raul Santos: International Collaborative Insights into the Treatment of Homozygous FH
Raul Santos, Researcher at ARO Hospital Israelita Albert Einstein, shared on LinkedIn about a recent article he and his colleagues co-authored, adding:
“The therapy of Homozygous FH (HoFH) is a great challenge due to the extreme elevated LDL-C levels and the genetic variability that characterizes this disease.
Combination therapy is the rule to reduce LDL-C, and is classified in medications that depend on the LDL receptor function like statins, ezetimibe and PCSK9 inhibitors and those who are independent like Lomitapide and Evinacumab.
In this collaborative study between Canada, South Africa and Brazil led by John Mancini we showed that statins also reduce LDL-C by mechanisms other than depending on the LDL receptor alone.
HoFH is a devastating disease that needs to be diagnosed and treated ASAP.
Novel therapies are coming and hopefully will change for good how we treat this disease!”
Article: Assessment of LDL receptor-dependent lipid lowering therapies in patients with homozygous familial hypercholesterolemia according to functional genotype.
Authors: G.B.John Mancini, Arnold Ryomoto, Isabelle Ruel, Iulia Iatan, Jacques Genest, Frederick J. Raal, Raul D. Santos, Ana Paula Marte, Brooke A. Kennedy, Liam R. Brunham, Daniel Gaudet, Miriam Larouche, Diane Brisson, Robert A. Hegele
Read the Full Article on Atherosclerosis
Stay updated on all scientific advances with Hemostasis Today.
-
Apr 16, 2026, 03:51William Wallace: How Vitamin B12 Is Being Absorbed?
-
Apr 16, 2026, 03:36Santagata Davide: Atypical Vascular Events Revealing Underlying Clonal Autoinflammation
-
Apr 16, 2026, 03:35Iron Deficiency in Women During Reproductive Years – ASH
-
Apr 16, 2026, 03:33Abdallah Othman: Overview of Coronary Arterial Anatomy and Its Clinical Implications
-
Apr 16, 2026, 03:14Laura Girardi: A Survey Study on the Management of Incidental Pulmonary Embolism in Patients with Cancer
-
Apr 16, 2026, 03:10Folusho Adeosun: Your 30-Minute Plan for SCD Emergencies
-
Apr 16, 2026, 02:57Charlie Windri: CAC as the Missing Link in Lp(a) Risk
-
Apr 15, 2026, 21:27Satish Bondala: Blood Bank and Transfusion Services – The Lifeline of Hospitals
-
Apr 15, 2026, 21:26Tareq Abadl: Understanding Thalassemia – Breaking the ‘Ordinary Anemia’ Myth