A Distinctive Immune Signature in Thrombocytopenic Sepsis
Journal of Thrombosis and Haemostasis (JTH) posted on LinkedIn:
”A distinctive immune signature in thrombocytopenic sepsis
By Maria Mulet, Rubén Osuna-Gómez, Laura Martínez-España, Iris Artesero, Pol Duch Llorach, Paula Vera Artázcoz, Maria Torrens-Sonet, Nuria Rodriguez Farriolé, Noelia Villalta, Andrés Abril-Gamboa, Montserrat Seres, Elisabet Cantó, Ma. Àngels Ortiz, Joaquin Lopez-Contreras, and Silvia Vidal
Thrombocytopenic patients displayed hyperactivated PD-L1⁺ CXCR4⁺ platelets, dysfunctional neutrophil–platelet complexes, and elevated plasma MPO-DNA and S100A8/A9, signifying immune exhaustion despite pro-inflammatory signaling.
This platelet–neutrophil immunoparalysis phenotype links hemostatic dysregulation to organ failure risk, spotlighting PD-L1⁺ platelets and NET-associated markers as potential biomarkers or therapeutic targets in severe sepsis.
Read the article here.”
Title: A distinctive immunophenotypic signature in thrombocytopenic septic patients: platelet and neutrophil dysregulations as key contributors to disease severity
Authors: Maria Mulet, Rubén Osuna-Gómez, Laura Martínez-España, Iris Artesero, Pol Duch-Llorach, Paula Vera-Artázcoz, Maria Torrens-Sonet, Núria Rodríguez-Farré, Noelia Vilalta, Andrés Abril-Gamboa, Montserrat Seres, Elisabet Cantó, Ma. Àngels Ortiz, Joaquín López-Contreras, Silvia Vidal
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