Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
October, 2026
October 2026
M T W T F S S
 1234
567891011
12131415161718
19202122232425
262728293031  
W. Alberto Sifuentes Giraldo: Exploring Peripheral Macrovascular Thrombosis in CAPS
W. Alberto Sifuentes Giraldo/LinkedIn
Oct 17, 2026, 16:24

W. Alberto Sifuentes Giraldo: Exploring Peripheral Macrovascular Thrombosis in CAPS

W. Alberto Sifuentes Giraldo, Rheumatologist at Hospital Nuestra Señora de Sonsoles (Sacyl), shared a post on X about a recent article by Berta Vilaplana et al., published in Seminars in Arthritis and Rheumatism, adding:

“Peripheral macrovascular thrombosis in CAPS: 1 in 3 episodes, high amputation risk with arterial events

A new analysis of the CAPS Registry (843 patients) shows peripheral macrovascular thrombosis in 33.2% of episodes.

Main findings

  • Events were predominantly venous (58.3%), followed by arterial (30.6%) and combined arterial-venous (11.2%).
  • Both venous and arterial thromboses most often affected the lower limbs and proximal segments.
  • Arterial events carried a high major-amputation risk (28 cases = 24% of arterial episodes).
  • More common in men, when CAPS was the first APS manifestation, and with infection or malignancy triggers.
  • Episodes without macrovascular thrombosis had more SLE, triple antiphospholipid antibody positivity, thrombotic microangiopathy features, and multiorgan involvement.
  • Mortality did not differ significantly

Conclusions and implications

Peripheral macrovascular thrombosis is a common and relevant CAPS manifestation, most often presenting as proximal lower-limb deep vein thrombosis. Peripheral arterial thrombosis substantially contributes to long-term morbidity via elevated major amputation risk.

These findings highlight the need for early recognition and support distinctions between macrovascular and microvascular/TMA-dominant presentations of CAPS.

Vilaplana B, Russa A, Jerez A, et al; CAPS Registry Project Group/European Forum on Antiphospholipid Antibodies.

Peripheral macrovascular thrombosis in catastrophic antiphospholipid syndrome (CAPS): a descriptive analysis from the ‘CAPS Registry.'”

Title: Peripheral macrovascular thrombosis in catastrophic antiphospholipid syndrome (CAPS): A descriptive analysis from the “CAPS Registry”

Authors: Berta Vilaplana, Angelina Russa, Alba Jerez, Isaac Pons, Ana Ponce, Pilar Toledano, Tomeu Rossiñol, Ignasi Rodríguez-Pintó, Doruk Erkan, Gerard Espinosa, Ricard Cervera

W. Alberto Sifuentes Giraldo

Other posts featuring W. Alberto Sifuentes Giraldo on Hemostasis Today.

Alba Jerez Ana Ponce Angelina Russa Antiphospholipid Antibodies Berta Vilaplana CAPS Catastrophic Antiphospholipid Syndrome Doruk Erkan Gerard Espinosa Health Hematology Hemostasis Hemostasis News Hemostasis Today Ignasi Rodríguez-Pintó Isaac Pons Medicine Pilar Toledano Ricard Cervera Tomeu Rossiñol W. Alberto Sifuentes Giraldo
NewsFeed