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Marieke Kruip on Sex differences in Outcomes of VKA Treatment in Patients with Mechanical Heart Valve
Marieke Kruip/LinkedIn
Nov 10, 2025, 10:14

Marieke Kruip on Sex differences in Outcomes of VKA Treatment in Patients with Mechanical Heart Valve

Marieke Kruip, Professor haematology and quality of care at Erasmus MC, shared on LinkedIn:

”Our research on differences in the quality of anticoagulation treatment and clinical outcomes between men and women with mechanical heart valves has been published!

Our article on treatment with vitamin K antagonists shows that in women—particularly those under 55 years of age—the INR is less often within the therapeutic range and fluctuates more than in men.

Furthermore, the risk of thrombotic or bleeding complications also appears to be higher in women under 55 compared to men.

This calls for greater attention to sex-specific approaches in anticoagulation care!”

Read the full article in JTH.

Article: Sex differences in outcomes of vitamin K antagonist treatment in patients with a mechanical heart valve: a Dutch population-based cohort study

Authors: Eva K. Kempers, Chantal Visser, Jaap Seelig, Qingui Chen, Henk J. Adriaansen, Maarten J. Beinema, Arina J. ten Cate-Hoek, Laura M. Faber, Charlotte E.A. Dronkers, Melchior C. Nierman, Roger K. Schindhelm, Nynke M. Wiersma, Alexander D.M. Stork, Frederikus A. Klok, Frank W.G. Leebeek, Ron Pisters, Suzanne C. Cannegieter, Raffaele De Caterina, Martin E.W. Hemels, Hugo ten Cate, Maryam Kavousi, Marieke Kruip

Marieke Kruip on Sex differences in Outcomes of VKA Treatment in Patients with Mechanical Heart Valve

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Alexander D.M. Stork Anticoagulation Arina J ten Cate-Hoek Chantal Visser Charlotte E.A. Dronkers Erasmus MC Eva K Kempers Frank W. G. Leebeek Frederikus A Klok Health Hematology Hemostasis Hemostasis Today Henk J. Adriaansen Hugo ten Cate INR Jaap Seelig JTH Laura M. Faber Maarten J. Beinema Marieke Kruip Martin E.W. Hemels Maryam Kavousi mechanical heart valve Medicine Melchior C Nierman Nynke M Wiersma Qingui Chen Raffaele De Caterina Roger K Schindhelm Ron Pisters Suzanne C Cannegieter thrombosis VKAs
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