Juan Andrés De Pablo Moreno and Colleagues on Therapeutic FVIII Administration in Hemarthrosis in Mice
Journal of Thrombosis and Haemostasis (JTH) shared on LinkedIn:
”Defective lymphangiogenesis and iron removal after hemarthrosis in factor VIII–deficient mice are rectified with therapeutic factor VIII administration — implications for joint health
By Bilgimol Chumappumkal Joseph, Juan Andrés De Pablo Moreno, Nicca Falah, Mia Lora Cacho, and Annette von Drygalski
Recurrent joint bleeding in hemophilia leads to iron deposition, impaired lymphangiogenesis, and progressive arthropathy.
In a murine model of factor VIII deficiency, researchers compared saline, short-course recombinant FVIII, and prolonged murine Fc-FVIII therapy following induced knee hemarthrosis.
Sustained FVIII activity (~30–40%) enabled normal lymphangiogenesis, rapid iron clearance, and cartilage recovery, whereas short or absent replacement resulted in synovial iron overload and poor repair.”
Read the full article in JTH.
Article: Defective lymphangiogenesis and iron removal after hemarthrosis in factor VIII-deficient mice are rectified with therapeutic factor VIII administration—implications for joint health
Authors: Bilgimol Chumappumkal Joseph, Juan Andrés De Pablo Moreno, Nicca Falah, Mia Lora Cacho, Annette von Drygalski
Stay updated on all scientific advances with Hemostasis Today.
-
Apr 14, 2026, 13:09Yan Leyfman: Rewriting Sickle Cell Disease Biology with CRISPR Technology
-
Apr 14, 2026, 13:01Shahzaib Maqbool: Preeclampsia Through a Hematology Lens
-
Apr 14, 2026, 12:46Rosa Hart: Inside Pediatric Stroke Recovery with Dr. Catherine Schuster
-
Apr 14, 2026, 12:39Gonzalo Ladreda: Innovation in Stroke Care Is About Timing, Integration, and Real-World Usability
-
Apr 14, 2026, 12:30Roy P.C. Kessels: Stroke’s Cognitive Impact on Young Adults Is Significant and Often Overlooked
-
Apr 14, 2026, 12:22Mehari Gebreyohanns: New Insights on Wake-Up Strokes from Emergency Settings in Texas and Louisiana
-
Apr 14, 2026, 12:08Enrico Ferro: Comparative Study Raises Questions on PFA Safety in AF at EHRA 2026
-
Apr 14, 2026, 11:39Prachi Patel: How B Vitamins and Large-Scale Research Are Shaping Stroke Prevention
-
Apr 14, 2026, 11:28Jamie Brannigan: Help Shape the Future of Brain-Computer Interfaces in Stroke and Neurological Care