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Dennis Wolf Investigates How Visceral Fat Drives Systemic Inflammation
Nov 19, 2025, 02:51

Dennis Wolf Investigates How Visceral Fat Drives Systemic Inflammation

Dennis Wolf, Professor of Cardiovascular Systems Immunology at University of Freiburg, shared a post on LinkedIn:

“Which organ drives the highest level of systemic inflammation?
Is adipose tissue inflammation dependent on inflammasomes?
And how can ASC specks act as a “memory” of past tissue inflammation?

We address these questions in our new manuscript just published in Circulation Research.

Title: Externalized Inflammasomes in Visceral Fat Sustain Obesity-Related Inflammation

Authors: Julius Wissemann, Adrian Heidenreich, Dymphie Suchanek, Christoph Koentges, Juliane Engelmann, Malte Jung, Lorenz Karnbrock, Timoteo Marchini, Andrew Pospisilik, Gabriel Seifert, Olaf Groß, Mark Colin Gissler, Ingo Hilgendorf, Constantin von zur Mühlen, Andreas Zirlik, Dirk Westermann, Peter Stachon, Dennis Wolf, Julian Merz

Dennis Wolf Investigates How Visceral Fat Drives Systemic Inflammation

Huge thanks to Julian Merz, who led this work in the Vascular Immunology Lab at the University Heart Center Freiburg, Germany.”

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