Metabolic Reprogramming in Deep Vein Thrombosis: A Novel Therapeutic Avenue Beyond Anticoagulation
Flora Peyvandi, Professor of Internal Medicine at the University of Milan and former president of ISTH, recently shared an honoring post on X:
”Metabolic pathways in deep vein thrombosis: a new frontier for therapeutic intervention. This is a fascinating paper. Congratulations to the authors!”
Read the full article here.
Traditional anticoagulants do their job well—until they start doing it a little too well, turning the prevention of clots into a new risk: bleeding, especially when you need them the most over time.
In the new study published by Ivan Budnik et al. in Blood Journal by American Society of Hematology (ASH), metabolic pathways responsible for clot formation are seen as alternatives for treatment focus.
Preclinical studies reveal that targeting metabolic pathways can reduce thrombus formation without compromising hemostasis.
This metabolism-focused paradigm offers promising therapeutic potential, aiming to prevent or mitigate DVT while minimizing bleeding risk, and underscores the need for translational research into metabolic interventions as adjuncts or alternatives to anticoagulants.
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