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Do Natural Anticoagulant Deficiencies Worsen Ischaemic Stroke Severity?
Sodiq Lawal/LinkedIn
Dec 25, 2025, 04:07

Do Natural Anticoagulant Deficiencies Worsen Ischaemic Stroke Severity?

Sodiq Lawal, Peer Reviewer Interventional Neuroradiology at Sage, shared on LinkedIn:

“Could deficiencies in natural anticoagulants influence how severe an ischaemic stroke becomes, especially in under-studied African populations?
I’m pleased to share our newly published study examining Protein C and Protein S levels in Nigerian adults with acute ischaemic stroke and how they relate to stroke severity and functional outcomes.
Key findings:

  • Protein C levels were significantly lower in patients with ischaemic stroke compared with healthy controls
  • Lower Protein C showed a weak but significant correlation with stroke severity
  •  Protein S levels showed no significant difference
  •  Neither protein was associated with short-term functional outcomes

Why this matters:

Our findings suggest that Protein C deficiency may reflect stroke severity rather than recovery, raising important questions about its pathophysiological role and potential utility as a biomarker in low-resource settings, where stroke burden is rising rapidly.

Read the paper here:

Do Natural Anticoagulant Deficiencies Worsen Ischaemic Stroke Severity?

I’d really value perspectives from clinicians and researchers:

Do you see a role for thrombophilia markers like Protein C in stroke risk stratification or research, particularly in LMICs?”

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Anticoagulant Deficiencies Hemostasis Hemostasis Today ischaemic stroke Sodiq Lawal
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