Mostafa Faisal Mohammed: Avatrombopag in Aplastic Anemia
Mostafa Faisal Mohammed Saleh, Associate professor of Clinical Hematology and HSCT at Assiut University, shared on LinkedIn:
“Our recent publication and 1st in 2026 out in Therapeutic advances in Hematology (IF 3.1)
Avatrombopag in Aplastic Anemia – Review
- Scope: 10 studies (2023–2025), diverse AA settings (frontline, R/R, elderly, liver disease)
- Efficacy: ORR 55–85%; CR up to ~30%
- Onset: Rapid responses, typically within 1–2 months
- Clinical benefit: Multilineage recovery, reduced transfusion needs
- After eltrombopag: Responses seen even in EPAG-refractory/intolerant patients
- Safety: Favorable profile; no meaningful hepatotoxicity or clonal evolution reported
- Key advantage: Suitable for patients with liver dysfunction, no dietary restrictions
Bottom line: Avatrombopag is an effective, well-tolerated TPO-RA with growing role in AA across disease stages”
Title: Efficacy and safety of avatrombopag in aplastic anemia: a comprehensive review of clinical evidence
Authors: Mostafa F. Mohammed Saleh, Abdulrahman Nasiri D, Ahmed Kotb Abdrabou, Alfadil Haroon, Hadeel Samarkandi, Hazza Alzahrani, Mahmoud Aljurf, Ali Alahmari
Read full article here.
Stay updated on the latest scientific advances in the field of aplastic anemia with Hemostasis Today.
-
May 28, 2026, 05:29Kidist K.: First Balloon Pulmonary Angioplasty Performed as New CTEPH Program Launches
-
May 28, 2026, 04:59Maria Sol Andres: Exploring Lipid Disorders in Modern Cancer Care
-
May 28, 2026, 04:42Francesca Granata: Representing the Porphyria Community at the 79th World Health Assembly
-
May 28, 2026, 04:29Samone Cook: When Collaboration Turns Into Organizational Coagulation
-
May 28, 2026, 03:42Lara Bloom: 15,000 Steps, Countless Conversations – One Unforgettable WHA79
-
May 27, 2026, 23:00Octavio Marques Pontes-Neto: Exchanging Latin American Experiences at the Global Stroke Alliance Meeting in Buenos Aires
-
May 27, 2026, 17:51Nita Radhakrishnan: Post Graduate Institute of Child Health Receives WFH Data Quality Certification for Excellence
-
May 27, 2026, 17:51Fiona Robinson: What exactly Are Rebalancing Agents for Bleeding Aisorders?
-
May 27, 2026, 17:14Khurram Nasir: Can Earlier LDL-C Lowering Change the Trajectory of Cardiovascular Disease?