Alan Nurden: Discovering Platelet PITTs and a New Phenomenon in Biology
Alan Nurden, Emeritus Research Director at CNRS, Co-Founder of the French National Reference Centre for Inherited Platelet Disorders (CRPP), shared a post on LinkedIn about a recent article he and his colleagues co-authored, adding:
”My thanks go to Bernhard Nieswandt, David Stegner and their colleagues for their confidence and allowing my participation in their outstanding work at the University of Würzburg. This is highlighted by this publication in the journal Science, showing how under flow platelets produce integrin- and tetraspanin-enriched tethers (PITTs) that they leave behind at sites of inflammation and/or infection while returning to the circulation in a reduced functional state. This is a new phenomenon in biology that may apply to other blood cells.
Not least is the potential implication of PITTs in vesiculation and in a whole range of other pathological processes.”
Title: Platelet-derived integrin- and tetraspanin-enriched tethers exacerbate severe inflammation
Authors: Charly Kusch, David Stegner, Lukas J. Weiss, Paquita Nurden, Philipp Burkard, Denise Johnson, Wolfgang Bergmeier, Ceylan Onursal, Stefano Navarro, Christian Hackenbroch, Dennis Pfeiffer, Sabrina Ivana Bonfiglio, Mara Meub, Carina Gross, Joachim Schenk, Valeria Fumagalli, Kristina Mott, Markus Bender, Matteo Iannacone, Oliver Andres, Wolfgang Kastenmüller, Katrin G. Heinze, Markus Sauer, Harald Schulze, Klaus Ley, Alan T. Nurden, Bernhard Nieswandt
Read the Full Article on Science.
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