Piezo1 Gain-of-Function Mutation Explains Thromboembolic Complications in Hereditary Xerocytosis – JTH
Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Christilla Bachelot-Loza et al, adding:
”Piezo1 gain of function induces a platelet preactivation state
Piezo1 gain-of-function mutations create a platelet preactivation state that enhances thrombosis risk, explaining thromboembolic complications in hereditary xerocytosis patients and revealing mechanosensitive ion channels as critical regulators of platelet hemostatic function.”
Title: Piezo1 gain of function induces a platelet preactivation state
Authors: Christilla Bachelot-Loza, Aurore Marchelli, Laurie Ruch, Divina El Hamaoui, Julien Demagny, Bruna Salau Grau, Clarisse Mouriaux, Wafa Amara, Anaïs Mehl, Emma Ziessel, Shaymaa Alhabib, My Ngoc Ha, Fatima Zemali, Sophie Gandrille, Véronique Picard, Pierre Mangin, Régis Bobe, Loïc Garçon, Catherine Léon, Pascale Gaussem
Read the Full Article on Journal of Thrombosis and Haemostasis.
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