Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
October, 2026
October 2026
M T W T F S S
 1234
567891011
12131415161718
19202122232425
262728293031  
Quintijn Bonnez: Detecting ADAMTS13 Structural Changes with Conformation-Sensitive Antibody 1C4
Quintijn Bonnez/KU Leuven; Karen Vanhoorelbeke/LinkedIn
Apr 9, 2026, 15:04

Quintijn Bonnez: Detecting ADAMTS13 Structural Changes with Conformation-Sensitive Antibody 1C4

Quintijn Bonnez, Early-Career Board Member at Belgian Society on Thrombosis and Haemostasis, shared on LinkedIn:

”New book chapter in Methods in Molecular Biology by Springer Nature.

We here describe how the conformation-sensitive Antibody 1C4 can be used to detect structure changes in ADAMTS13.

In closed ADAMTS13, the 1C4 epitope remains cryptic and only upon opening, potent 1C4 binding occurs.

Just a structural curiosity, or much more?

Over the last decade, we investigated the molecular mechanisms of ADAMTS13 conformation changes in Health and Disease.

Emerging as a powerful Biomarker, open ADAMTS13 supports the diagnosis of acute immune-mediated TTP and the prediction of early relapse risk.

Read all methodological details.

Interested in broader methodologies for ADAMTS and ADAMTS-like proteases?

Find the full book.”

Title: Determining ADAMTS13 Conformation for the Diagnosis of Immune Thrombotic Thrombocytopenic Purpura and Prediction of Relapse

Authors: Quintijn Bonnez, Karen Vanhoorelbeke

Read the Full Article on ADAMTS Proteases

Quintijn Bonnez: Detecting ADAMTS13 Structural Changes with Conformation-Sensitive Antibody 1C4

Stay updated on all scientific advances with Hemostasis Today.

1C4 ADAMTS Proteases ADAMTS13 bleeding disorders Health Hematology Hemostasis Hemostasis News Hemostasis Today Karen Vanhoorelbeke Medicine Methods in Molecular Biology Quintijn Bonnez Springer Nature
NewsFeed