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Kevin Land: Near Elimination of Vaso-Occlusive Crises in Sickle Cell Disease
Kevin Land/LinkedIn
Apr 14, 2026, 09:09

Kevin Land: Near Elimination of Vaso-Occlusive Crises in Sickle Cell Disease

Kevin Land, Interim Laboratory and Medical Director Adult HSC Lab at UPMC Hillman Cancer Center, shared a post on LinkedIn։

“How cool is this clinical impact?

Deep normalization of hemoglobin with near‑elimination of vaso‑occlusive events in most treated patients, achieved by directly reactivating fetal hemoglobin at the γ‑globin promoters.

Compared with standard sickle cell care, often with multiple vaso-occlusive crises a year per patient, this represents a step‑change, from disease mitigation and symptomatic care to functional correction.

Early data suggests durable benefit driven by stable stem‑cell editing.”

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