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Samwel Mikaye: From Virchow’s Triad to Prevention of PE in Patients with DVT
Dr. S.0 MIKAYE / LinkedIn
Apr 14, 2026, 14:48

Samwel Mikaye: From Virchow’s Triad to Prevention of PE in Patients with DVT

Samwel Mikaye, Medical Doctor at MSK, shared a post on LinkedIn:

“Deep vein thrombosis (DVT) is a condition where a blood clot forms in the deep veins, most commonly in the lower limb (calf or thigh).

It is dangerous because the clot can travel to the lungs and cause a pulmonary embolism.

Causes (Virchow’s triad)

DVT is mainly caused by three factors:

1. Venous stasis (slow blood flow)

  • Long bed rest
  • Prolonged travel (sitting for long hours
  • Paralysis

2. Endothelial injury (vessel damage)

  • Surgery
  • Trauma
  • IV catheters

3. Hypercoagulability (increased clotting tendency)

  • Pregnancy
  • Cancer
  • Oral contraceptives
  • Genetic clotting disorders

Symptoms

  • Swelling of one leg (unilateral)
  • Pain or tenderness in calf
  • Warmth in affected leg
  • Redness or discoloration
  • Prominent veins

Dangerous complication

  • Pulmonary embolism (clot moves to lungs)
  • Sudden chest pain
  • Shortness of breath
  • Collapse (life-threatening)

Diagnosis

  • Doppler ultrasound (first line)
  • D-dimer test (screening)
  • CT/MR venography (if needed)

Treatment

1. Anticoagulation (main treatment)

  • Heparin (initial)
  • Warfarin or DOACs (long-term)

2. Supportive care

  • Leg elevation
  • Pain relief
  • Compression stockings

3. Severe cases

  • Thrombolysis (clot dissolving drugs)
  • Inferior vena cava (IVC) filter if anticoagulants cannot be used

Prevention

  • Early mobilization after surgery
  • Hydration
  • Compression stockings
  • Avoid long immobility

DVT is ‘Deep clot in leg leads to Danger to lungs.’ ”

Samwel Mikaye: From Virchow's Triad to Prevention of PE in Patients with DVT

Other posts  featuring Samwel Mikaye on Hemostasis Today.

endothelial injury Health Hematology Hemostasis Hemostasis News Hemostasis Today Hypercoagulability Medicine PE Pulmonary Empolism Samwel Mikaye thrombosis Venous stasis Virchow’s Triad
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