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Platelet DGD – A Common But Underdiagnosed Bleeding Disorder – RPTH
RPTH/LinkedIn
Apr 16, 2026, 04:03

Platelet DGD – A Common But Underdiagnosed Bleeding Disorder – RPTH

Research and Practice in Thrombosis and Haemostasis (RPTH) shared a post on LinkedIn about The Recent Article by Delphine Borgel, adding:

“Platelet dense granule defect: a common but underdiagnosed bleeding disorder

Dense granule defect (DGD) is one of the most frequent inherited platelet disorders, yet it remains widely underdiagnosed, largely due to the complexity of diagnostic tools and a lack of standardization.

A new study published in RPTH Journal assessed the real-world prevalence of DGD in a large French cohort 🇲🇫 of patients with unexplained bleeding symptoms.

Key findings from 119 patients across 8 expert centers:

  • DGD prevalence ranged from 7.5% to 37.4%, depending on the diagnostic criteria applied
  • 66 patients had at least 1 abnormal dense granule test at the first visit
  • Repeated testing at a confirmatory visit was key: abnormalities were not always reproducible
  • No significant differences in age, sex, or bleeding scores between patients with or without confirmed DGD

The wide prevalence range highlights a critical issue: without standardized criteria, DGD diagnosis is highly variable, and many patients may be missed or misclassified.”

Title: Platelet dense granule defect: experience in the French population

Authors: Delphine Borgel, Agathe Beauvais, Cécile Bally, Manal Ibrahim-Kosta, Annabelle Dupont, Camille Paris, Caroline Vayne, Sophie Voisin, Valérie Goin, Guillaume Nam-Nguyen, Rémi Favier, Arnaud Dupuis, Sebastien Eymieux, Jean-Claude Bordet, Emmanuelle Blanchard, Claire Auditeau, Dominique Lasne, Annie Harroche, Marie-Christine Alessi, Mathieu Fiore

RPTH

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Agathe Beauvais Annabelle Dupont Annie Harroche Arnaud Dupuis bleeding disorders Camille Paris Caroline Vayne Cécile Bally Claire Auditeau Delphine Borgel Dense granule defect DGD Dominique Lasne Emmanuelle Blanchard Guillaume Nam-Nguyen Health Hematology Hemostasis Hemostasis News Hemostasis Today ISTH Jean-Claude Bordet Manal Ibrahim-Kosta Marie-Christine Alessi Mathieu Fiore Medicine Rémi Favier rpth Sébastien Eymieux Sophie Voisin Valérie Goin
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