Maria Kuzmina: How Chronic Inflammation Affects Extramedullary Hematopoiesis
Maria Kuzmina, Clinical Biochemist, Immunologist at Institute of Molecular Genetics of the Czech Academy of Sciences, shared on LinkedIn about a recent article she and her colleagues co-authored, published in Science Advances, adding:
”It’s been a week and it still feels a bit surreal to see it out there.
My PhD research has been p5gublished in Science Advances (Science Magazine)!
Publishing in a journal like this was a goal I set at the very beginning of my PhD and it’s what kept me going when things were tough.
This wouldn’t have been possible without the guidance of my supervisor Meritxell Alberich-Jordà and an incredible team of collaborators from Institute of Molecular Genetics of the Czech Academy of Sciences and beyond.
In this work, we studied how chronic inflammation affects extramedullary hematopoiesis, an area that is still relatively poorly understood.
We show that hematopoietic stem and progenitor cells are not just passively relocated under stress.
Instead, they actively adapt and establish a bidirectional interaction with Tregs – promoting their development while being protected by them in return.
Furthermore, our findings suggest that chronic inflammation can reshape normally inactive bone marrow niches into functional hematopoietic sites, even in unexpected locations such as inflamed paws.
Altogether, this suggests that blood formation is not simply relocated during stress, but locally adapted in ways we are only beginning to understand.”
Title: HSPCs and Treg cells cooperate to preserve extramedullary hematopoiesis under chronic inflammation
Authors: Maria Kuzmina, Srdjan Grusanovic, Jiri Brezina, Flavian Thelen, Karolina Vanickova, Mirko Milosevic, Irina Ribeiro Bas, Nataliiia Pavliuchenko, Sarka Ruzickova, Jakub Rohlena, Dominik Filipp, Katerina Rohlenova, Cesar Nombela-Arrieta, Tomas Brdicka, Meritxell Alberich-Jorda
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