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PROTECmo Study: Thrombocytopenia in VenoVenous ECMO Linked to High Bleeding Risk
Nina Buchtele/University Hospital Vienna
Aug 10, 2025, 01:12

PROTECmo Study: Thrombocytopenia in VenoVenous ECMO Linked to High Bleeding Risk

Marta Velia Antonini, Hematologist, Perfusionist ECMO and NRP Specialist and Chair of the Normothermic Regional Perfusion EuroELSO Working Group,  shared on X:

”Thrombocytopenia in VV ECMO? Highly prevalent in VV ECMO, and strongly associated with bleeding risk and reduced survival.

Platelet transfusions do not appear to significantly reduce bleeding risk: targeted prevention strategies needed!

  • Adults with respiratory failure; baseline thrombocytopenia 27.9%, mild 14.7%, moderate 8.7%, severe 4.4%
  • Thrombocytopenia in ECLS occurred at least once in 80.2%; mild 21.3%, moderate 32.2%, severe 26.7%
  • Mild thrombocytopenia increased risk of bleedings by 61%; moderate and severe by 90%
  • Risk for thrombocytopenia  increased with ICU days prior to ECMO, postop admission, immunocompromised state, RRT, septic shock, low hemoglobin, circuit replacement.”

Read the full article in Critical Care.

Title: Incidence, kinetics, and clinical impact of thrombocytopenia in venovenous ECMO: insights from the multicenter observational PROTECMO study

Authors: Nina Buchtele, Kenichi Tanaka, Fabio Tuzzolino, Cara Agerstrand, Ali Ait Hssain, Jordi Riera, Peter Schellongowski, Matthieu Schmidt, Raj Ramanan, Martin Balik, Lars Mikael Broman, Nicolo Rizzitello, Konstanty Szułdrzyński, Whitney D. Gannon, Vito Fanelli, Brian Trethowan, Hergen Buscher, Huda Alfoudri, Marco Giani, Alain Combes, Giacomo Grasselli, Roberto Lorusso, Antonio Arcadipane, Daniel Brodie, Gennaro Martucci, PROTECMO Study group

PROTECmo Study: Thrombocytopenia in VenoVenous ECMO Linked to High Bleeding Risk

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Alain Combes Ali Ait Hssain Antonio Arcadipane Bleeding Risk Brian Trethowan Cara Agerstrand Daniel Brodie ECMO Fabio Tuzzolino Gennaro Martucci Giacomo Grasselli Health Hematology Hemostasis Today Hergen Buscher Huda Alfoudri Jordi Riera Kenichi Tanaka Konstanty Szułdrzyński Lars Mikael Broman M Velia Antonini Marco Giani Marta Velia Antonini Martin Balik Matthieu Schmidt Medicine Nicolo Rizzitello Nina Buchtele Peter Schellongowski Platelet Transfusions PROTECMO Study group Raj Ramanan Roberto Lorusso thrombocytopenia Vito Fanelli Whitney D. Gannon
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