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Nicolas Nesseler: Do We Overlook Factor XIII Deficiency in VA-ECMO Patients?
Nicolas Nesseler/LinkedIn
May 25, 2026, 15:53

Nicolas Nesseler: Do We Overlook Factor XIII Deficiency in VA-ECMO Patients?

Nicolas Nesseler, Professor at University of Rennes, shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Critical Care Journal, adding:

”Do we overlook Factor XIII deficiency in VA-ECMO patients?

We just published a prospective study in Critical Care – 50 patients on VA-ECMO, 413 FXIII measurements.

68percent  spent most of their ECMO run with FXIII levels below 70percent. On average, 80percent of their support time in deficiency territory. And none of this is captured by routine PT or aPTT.

No clear trend over time. Huge variability between patients. No proven link with severe bleeding – but our sample size was limited.

The real question now: should we routinely monitor FXIII in these patients, and when does supplementation make sense?

Curious to hear from those managing ECMO patients daily.”

Title: Cumulative exposure to factor XIII deficiency during veno-arterial extracorporeal membrane oxygenation: a prospective cohort study

Authors: Nicolas Nesseler, Adeline Pontis, Erwan Flécher, Mathieu Beaudeau, Nicolas Patou-Parvedy, Isabelle Gouin-Thibault, Alexandre Mansour

Nicolas Nesseler: Do We Overlook Factor XIII Deficiency in VA-ECMO Patients?

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Adeline Pontis Alexandre Mansour Erwan Flecher Health Hematology Hemophilia Hemostasis Hemostasis News Hemostasis Today Isabelle Gouin–Thibault Mathieu Beaudeau Medicine Nicolas Nesseler Nicolas Patou-Parvedy
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