Wael AlAnazi: Exceptional HLA-Matched Transplant Outcomes With Novel Thiotepa-Based Conditioning
Wael AlAnazi, Chairman and Hematology-Oncology Consultant at King Fahad Specialist Hospital Dammam, shared Syed Osman Ahmed‘s post on LinkedIn, adding:
“Impressive results!!!
I think this may be reference for sickle cell disease transplantation.
Do you have similar observations in Thalassemia?”
Syed Osman Ahmed, Consultant and Adult Hematologist at King Faisal Specialist Hospital and Research Centre, shared a post on LinkedIn about a recent article by Reem Alasbali et al. published in Bone Marrow Transplantation, adding:
“Outstanding outcomes in HLA-matched related donor transplant in adolescents and adults with sickle cell disease!
- 100% 2 year survival
- 0% Transplant related mortality
- 0% graft failure
- 0% Chronic Graft versus host disease
- Only 4% severe acute GVHD
Practice changing.
Congratulations to the authors of this collaborative work by Reem Alasbali et al led by Ali AlAhmari of King Faisal Specialist Hospital and Research Center and teams from Ministry of National Guard Health Affairs, Riyadh, Vanderbilt University Medical Center, Nashville and Imperial College London.”
Title: Excellent outcomes using a novel reduced intensity conditioning with thiotepa and post-transplant cyclophosphamide for HLA-matched related donor transplant in adolescents and adults with sickle cell disease
Authors: Reem Alasbali, Mohsen Alzahrani, Karina Wilkerson, Phavina Akhom, Fahad Alotaibi, Bader Alahmari, Josu de la Fuente, Michael R. DeBaun, Walid Rasheed, Hadeel Samarkandi, Riad El Fakih, Mostafa Saleh, Tusneem Elhassan, Hazza Alzahrani, Mahmoud Aljurf, Fahad Almohareb, Adetola A. Kassim, Ali AlAhmari
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