Yvonne Jongejan: Allele-Selective Silencing Therapy for VWD and Thrombotic Disorders
Yvonne Jongejan, Postdoctoral researcher at Leiden University Medical Center, reposted from RPTH Journal on LinkedIn:
”A nice overview in RPTH of the work Annika de Jong, Noa Linthorst, Isabel Bär, Jeroen Eikenboom and myself have done and are still doing to develop an allele-selective silencing therapy for von Willebrand disease and thrombotic disorders.”
Quoting RPTH Journal‘s post about a recent article by Jeroen Eikenboom et al:
”What if the future of VWF therapy is not replacing the protein, but silencing the wrong allele?
This RPTH State-of-the-Art review highlights allele-selective VWF silencing: a precision siRNA strategy designed to switch off only one VWF allele.
For dominant-negative VWD, this could remove mutant VWF and restore healthier multimer formation. For thrombotic disorders linked to high VWF, it may offer a controlled way to lower VWF without pushing patients into bleeding risk.
One allele. Two clinical directions. A new precision-medicine angle for VWF biology.”
Title: Allele-selective von Willebrand factor silencing
Authors: Jeroen Eikenboom, Noa Linthorst, Yvonne Jongejan
Stay updated on all scientific advances with Hemostasis Today.
-
Jul 13, 2026, 23:39Yaariv Khaykin: Whole-Person Care Can Strengthen Stroke Prevention in Patients With Atrial Fibrillation
-
Jul 13, 2026, 22:33ESOC 2026 recordings are now available on eSTEP – European Stroke Organisation
-
Jul 13, 2026, 20:17Julia R. Coleman: Fantastic First Day at ISTH 2026
-
Jul 13, 2026, 20:11Ruah Alyamany: Combination Therapy Improves Quality of Life in ITP
-
Jul 13, 2026, 19:47Brian O Mahony: Two-Year Results of BBM-H901 Gene Therapy Presented at ISTH 2026
-
Jul 13, 2026, 19:37Sara Zalghout: Connecting With Colleagues From All Over the World at ISTH 2026
-
Jul 13, 2026, 18:54Alfonso J. Tafur: New Evidence on Perioperative Anticoagulation in Cancer at ISTH 2026
-
Jul 13, 2026, 18:42Jessica Garcia: Thrombin Generation in Type 3 VWD With an Inhibitor on Emicizumab
-
Jul 13, 2026, 18:19Fionnuala Ní Áinle: High-Quality Evidence for DVT Diagnosis in Pregnancy at ISTH 2026