Johann Morelle: Complement Inhibitors Are Reshaping Modern Nephrology
Johann Morelle, Professor of Nephrology, Head of the Division of Nephrology at University Hospitals Namur (CHU UCL Namur), shared a post on LinkedIn about a recent article he and his colleagues co-authored, published in Nephrology Dialysis Transplantation:
“Complement inhibitors are rapidly transforming the management of kidney diseases – from complement-mediated thrombotic microangiopathies (TMA/aHUS) to glomerular diseases such as C3 glomerulopathy (C3G), primary immunoglobulin-associated MPGN (Ig-MPGN) and IgA nephropathy (IgAN).
In our new review published in Nephrology Dialysis Transplantation (NDT), the journal of the European Renal Association (ERA), we discuss the mechanistic basis of infection risk under complement inhibition (eculizumab, ravulizumab, iptacopan, pegcetacoplan) and propose a pragmatic framework for infection-risk mitigation in nephrology practice.
Key take-home messages:
- Infection risk under complement inhibition is target-dependent
- Prevention strategies should integrate vaccination, antimicrobial prophylaxis, patient education, and rapid-access pathways for febrile illness
- CKD, dialysis, transplantation, and concomitant immunosuppression further modulate infectious vulnerability.
Grateful to Mathilde Berghmans, Francois Seghers, Safak Mirioglu, and Andreas Kronbichler for the outstanding collaboration!”
Title: Infection risk mitigation with complement inhibitors in kidney disease
Authors: Mathilde Berghmans, François Seghers, Safak Mirioglu, Andreas Kronbichler, Johann Morelle
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 20, 2026, 01:43Oliver Weingärtner: Deprescribing of Lipid Lowering Drug after MI is Associated with Cardiovascular Events
-
Oct 19, 2026, 19:44Where You Live Should not Determine Whether You Receive Care – World Federation of Hemophilia
-
Oct 19, 2026, 19:42Belen Bianco: Prevention, Early Suspicion and an Interdisciplinary Approach Save Lives
-
Oct 19, 2026, 19:40Christina Chrysohoou: Catheter-Based LAAC vs OAC for Stroke Prevention in Atrial Fibrillation
-
Oct 19, 2026, 19:38Matthew Flick: A Two-Day Research Meeting on Fibrinogen, Hemostasis and Thrombosis
-
Oct 19, 2026, 19:37Hayat Saeed: Excited to Share Our Publication on the FGL1–Hepcidin Axis in Iron Homeostasis and Disease
-
Oct 19, 2026, 19:08IPAW 2026 Comes to a Close, but the Work Continues – PPTA
-
Oct 19, 2026, 17:44Paul Riley: Moderating a Webinar on Anticoagulation Monitoring
-
Oct 19, 2026, 16:36Christopher Pittman: Blood Clot Prevention Cannot End at Hospital Discharge