Open-Conformation ADAMTS13 R1206K as a Next-Generation Therapeutic Candidate for TTP – JTH
Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Szu-Mam Liu et al. published in JTH, adding:
“ADAMTS-13 R1206K Variant Exhibits an Open Conformation and an Enhanced Proteolytic Activity Toward von Willebrand Factor
The gain-of-function ADAMTS-13 R1206K variant demonstrates enhanced VWF cleavage, reduced autoantibody inhibition, and superior thrombus suppression under flow — offering a promising new therapeutic avenue for TTP.”
Title: ADAMTS-13 R1206K variant exhibits an open conformation and an enhanced proteolytic activity toward von Willebrand factor
Authors: Szumam Liu, Xiaxin Dong, Quintijn Bonnez, Zhirong Chai, Chan Meng, Madison Gil, Karen Vanhoorelbeke, Konstantine Halkidis, X. Long Zheng
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