Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
July, 2026
July 2026
M T W T F S S
 12345
6789101112
13141516171819
20212223242526
2728293031  
Open-Conformation ADAMTS13 R1206K as a Next-Generation Therapeutic Candidate for TTP – JTH
Szumam Liu/ LinedIn
Jun 2, 2026, 13:04

Open-Conformation ADAMTS13 R1206K as a Next-Generation Therapeutic Candidate for TTP – JTH

Journal of Thrombosis and Haemostasis (JTH) shared a post on LinkedIn about a recent article by Szu-Mam Liu et al. published in JTH, adding:

“ADAMTS-13 R1206K Variant Exhibits an Open Conformation and an Enhanced Proteolytic Activity Toward von Willebrand Factor

The gain-of-function ADAMTS-13 R1206K variant demonstrates enhanced VWF cleavage, reduced autoantibody inhibition, and superior thrombus suppression under flow — offering a promising new therapeutic avenue for TTP.”

Title: ADAMTS-13 R1206K variant exhibits an open conformation and an enhanced proteolytic activity toward von Willebrand factor

Authors: Szumam Liu, Xiaxin Dong, Quintijn Bonnez, Zhirong Chai, Chan Meng, Madison Gil, Karen Vanhoorelbeke, Konstantine Halkidis, X. Long Zheng

Open-Conformation ADAMTS13 R1206K as a Next-Generation Therapeutic Candidate for TTP - JTH

Stay updated on all scientific advances with Hemostasis Today.

ADAMTS-13 Chan Meng Health Hematology Hemostasis Hemostasis News Hemostasis Today Karen Vanhoorelbeke Konstantine Halkidis Madison Gil Medicine Quintijn Bonnez Szumam Liu TTP (thrombotic thrombocytopenic purpura) VWD X. Long Zheng Xiaxin Dong Zhirong Chai
NewsFeed