Kathleen Freson: αIIbβ3’s Hidden Role in Platelet Production
Kathleen Freson, Professor at KU Leuven, Chair of the International Society on Thrombosis and Haemostasis (ISTH), shared a post on LinkedIn about a recent article, she and her colleagues co-authord, published in Blood Journal, adding:
“Excited to share our latest publication in Blood, American Society of Hematology !
Glanzmann thrombasthenia (GT) has traditionally been viewed as a disorder of platelet function caused by defects in integrin αIIbβ3.
Our findings add to growing evidence that the story is more complex.
We show that αIIbβ3 deficiency is associated with impaired platelet production, driven in part by altered serine metabolism in megakaryocytes.
These results help explain the observation that several GT and all GT-like patients have low platelet counts, suggesting that αIIbβ3 is not only essential for platelet function but also plays an important role in platelet biogenesis.
This work provides new insights into the mechanisms regulating thrombopoiesis and highlights an unexpected link between integrin signaling, cellular metabolism, and platelet production.
Many thanks to all co-authors and collaborators who contributed to this study.
And especially congrats to Kato Ramaekers as this is mainly her PhD work !”
Title: Reduced platelet formation associated with serine metabolic dysregulation in integrin αIIbβ3-deficient megakaryocytes
Authors: Kato Ramaekers,My Tran,Marco Lunghi,Amy Hermans,Chantal Thys,Koenraad De Wispelaere,Ernest Turro,Christel Van Geet Van Geet, Quentin Van Thillo,Kathelijne Peerlinck,Koji Eto,Alan T. Nurden,Alessandra Balduini,Christian Andrea Di Buduo,Veerle Labarque,Kathleen Freson
Other articles featuring Kathleen Freson on Hemostasis Today.
-
Oct 21, 2026, 18:13Wolfgang Miesbach: Hereditary Hemorrhagic Telangiectasia An Overlooked Bleeding Disorder
-
Oct 21, 2026, 17:55Gayatri Kotwal։ New Review on Anemia, Pain, and Nutritional Deficiencies in Cancer Patients
-
Oct 21, 2026, 17:40Tetsuzan Ron: Iron Deficiency Without Anemia Clinical Impact and Management
-
Oct 21, 2026, 17:29Amir Hossien Esfandiari։ The Association Between Viral Infections and Aplastic Anemia
-
Oct 21, 2026, 17:16Melissa Hollo: A Meaningful Step Forward for Women’s Health
-
Oct 21, 2026, 17:09Chipili Ng’onga: Have You Ever Seen a Result That Just Didn’t Make Sense?
-
Oct 21, 2026, 16:57Fabrice Cognasse: Celebrating the Next Generation of Platelet Research and Transfusion Medicine
-
Oct 21, 2026, 16:47Christabel Odeta: Treating Pediatric Cancer in Children With Sickle Cell Disease
-
Oct 21, 2026, 16:36Sharlene Haywood: Bringing Multidisciplinary Learning Into Nursing Practice