Marc Carrier: Important New Data From the API-CAT Trial on Recurrent VTE During Extended Apixaban Therapy
Marc Carrier, Professor at Ottawa Hospital Research Institute, shared on LinkedIn about a recent article by Isabelle Mahé et al, published in Circulation, adding:
”Exciting results presented by Prof Isabelle Mahé at the International Society on Thrombosis and Haemostasis (ISTH) 2026 Congress in Paris, with simultaneous publication in Circulation.
Key findings from this pre-specified ancillary analysis of the API-CAT trial include:
- Recurrent VTE during extended apixaban therapy was uncommon, occurring in only 2.5% of 1,766 patients over 12 months.
- The risk of recurrence differed by cancer type, with the highest incidence observed in gastrointestinal cancers (excluding colorectal).
- The index VTE strongly predicted the pattern of recurrence. Patients presenting initially with PE were most likely to recur with PE, while those with isolated DVT recurred exclusively with DVT.
- Despite its low frequency, recurrent VTE carried a very poor short-term prognosis, with 50% mortality occurring within a median of just 24 days following recurrence.”
Title: Prognosis of Recurrent Venous Thromboembolism During Extended Apixaban Therapy for Cancer-Associated Thrombosis: Insights From the API-CAT Randomized Trial
Authors: Isabelle Mahé, Céline Chapelle, Marc Righini, Grégoire Le Gal, Frederikus A. Klok, Giancarlo Agnelli, Francis Cajfinger, Marie-Antoinette Sevestre, Philippe A. Grenier, Jérôme Alexandre, Francis Couturaud, Patrick Mismetti, Silvy Laporte, Jean Chidiac
Stay updated on all scientific advances with Hemostasis Today.
-
Oct 12, 2026, 21:51Sam Botchey: Orthobiologics Are Advancing but the Evidence Must Keep Pace
-
Oct 12, 2026, 21:50Serum Vitamin D, Platelet Function, and Bleeding in Primary ITP – Platelets Journal
-
Oct 12, 2026, 21:30Nika Samadzadeh Tabrizi: Looking Forward to the PACeS Trial on Anticoagulation for POAF
-
Oct 12, 2026, 21:28Michael Megaly: Does Coronary Ectasia Affect Outcomes in Acute Coronary Syndromes?
-
Oct 12, 2026, 21:25Vitor Borin P. de Souza: Think Twice Before Anticoagulating an Isolated Subsegmental PE
-
Oct 12, 2026, 20:43Jazlyn A Selvasingh: Excited to Share Our Research at AAO-HNSF 2026 in Los Angeles
-
Oct 12, 2026, 20:31Natalia Kovtun: Higher Ferritin Cutoffs Now Define Iron Deficiency
-
Oct 12, 2026, 19:39Edward Loftus: Using Low-Dose Aspirin in Pregnant Women With IBD
-
Oct 12, 2026, 19:32Shruti Sachdeva: Strengthening the Fight against Anemia