Kefah Mokbel: Beyond Thromboprophylaxis – Enoxaparin’s Emerging Anticancer Signal
Kefah Mokbel, Professor of Medicine (Honorary) at Cardiff University School of Medicine, shared a post on LinkedIn about a recent article by Sedat Carkit et al., published in Scientific Reports, adding:
“Beyond Thromboprophylaxis: Enoxaparin’s Emerging Anticancer Signal
A new study in Scientific Reports adds to the growing evidence that enoxaparin – long used simply to manage cancer-associated thrombosis – may have direct effects on tumour biology.
Using MDA-MB-231 (breast) and HepG2 (liver) cancer cell lines alongside non-cancerous HEK-293 controls, the authors treated cells with a range of enoxaparin concentrations and found:
- Significantly reduced viability in both cancer cell lines, with no cytotoxicity in normal cells
- Markedly increased apoptosis on TUNEL analysis
- Increased LC3/p62 expression, indicating activation of autophagy
- Differential inflammatory modulation – NF-κB rose in breast cancer cells alongside suppression of IL-6 and TNF-α, while liver cancer cells showed no significant inflammatory change
- Reduced extracellular 8-OHdG, suggesting less oxidative DNA damage
The selectivity – hitting cancer cells while sparing normal cells – is what makes this interesting. It’s in-vitro work, so it doesn’t change clinical practice today, but it strengthens the rationale for exploring enoxaparin’s role beyond thromboprophylaxis in oncology.”
Title: Enoxaparin induces apoptosis and autophagy, modulates inflammatory signaling, and reduces oxidative DNA damage in breast and liver cancer cells
Authors: Sedat Carkit, Münevver Baran, Nazmiye Bitgen, Gozde Ozge Onder, Damla Gündüz, Arzu Yay
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