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Intra-Arterial Tenecteplase Improves Outcomes After Stroke Thrombectomy: Insights from the ANGEL-TNK Tria
JAMA/X
Aug 22, 2025, 14:44

Intra-Arterial Tenecteplase Improves Outcomes After Stroke Thrombectomy: Insights from the ANGEL-TNK Tria

JAMA shared an insightful post on X:

“In patients with acute large vessel occlusion, intra-arterial tenecteplase after successful thrombectomy improved 90-day neurological outcomes without increasing hemorrhage or mortality.”

Title: Intra-arterial Tenecteplase for Acute Stroke After Successful Endovascular Therapy
The ANGEL-TNK Randomized Clinical Trial

Authors: Zhongrong Miao, Gang Luo, Ligang Song, Dapeng Sun, Wenhuo Chen, Xiaoxi Yao, Yuesong Pan, Yaou Liu, Guangxiong Yuan, Changming Wen, Ming Wei, Xueli Cai, Qingcheng Yang, Zhiming Zhou, Mingze Chang, Guangxian Nan, Jing Wang, Guangyu Xiang, Li Zhou, Wen Gao, Hong Zhang, Jiheng Hao, Chenghua Xu, Yaxuan Sun, Tingyu Yi, Ganghua Feng, Hongxing Han, Feng Gao, Ning Ma, Dapeng Mo, Xuan Sun, Yiming Deng, Xu Tong, Xiaoqing Li, Baixue Jia, Bo Wang, Zijun He, Ming Yang, Xingquan Zhao, Xuelei Zhang, Longhui Zhang, Shuo Li, Xin Tong, Jing Jing, Yunyun Xiong, Tao Liu, Zixiao Li, Zeguang Ren, Yilong Wang, David S. Liebeskind, Tudor G. Jovin, Thanh N. Nguyen, Yongjun Wang, Liping Liu, Bernard Yan, Xiaochuan Huo

Tenecteplase

Read the full article here.

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Acute Stroke ANGEL-TNK Baixue Jia Bernard Yan Bo Wang Changming Wen Chenghua Xu Dapeng Mo Dapeng Sun David S. Liebeskind endovascular therapy Feng Gao Gang Luo Ganghua Feng Guangxian Nan Guangxiong Yuan Guangyu Xiang Hematology hemorrhage Hemostasis Hemostasis Today Hong Zhang Hongxing Han JAMA Jiheng Hao Jing Jing Jing Wang Li Zhou Ligang Song Liping Liu Longhui Zhang Ming Wei Ming Yang Mingze Chang Ning Ma Qingcheng Yang Shuo Li Tao Liu Tenecteplase Thanh N. Nguyen Thrombectomy Tingyu Yi Tudor G. Jovin Wen Gao Wenhuo Chen Xiaochuan Huo Xiaoqing Li Xiaoxi Yao Xingquan Zhao Xu Tong Xuan Sun Xuelei Zhang Xueli Cai Yaou Liu Yaxuan Sun Yilong Wang Yiming Deng Yongjun Wang Yuesong Pan Yunyun Xiong Zeguang Ren Zhiming Zhou Zhongrong Miao Zijun He Zixiao Li
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