Hemostasis Today
NewsFeed
Headlines Hematology Health Medicine VTE ASH Plasma Donation
October, 2026
October 2026
M T W T F S S
 1234
567891011
12131415161718
19202122232425
262728293031  
Kamlesh Darji: Paraneoplastic Syndromes – Tumor with or without Mediator
Aug 24, 2026, 16:21

Kamlesh Darji: Paraneoplastic Syndromes – Tumor with or without Mediator

Kamlesh Darji, Senior Resident – Department of Pathology at AIIMS (All India Institute of Medical Sciences, New Delhi), shared a post on X:

“Paraneoplastic Syndromes : Tumor with or without Mediator

Endocrine

1. SIADH with hyponatremia : small cell lung carcinoma : ADH

2. Cushing syndrome : small cell lung carcinoma : ectopic ACTH

3. Hypercalcemia without bone metastasis : squamous cell carcinoma of lung, renal cell, breast, HTLV1 adult T cell leukemia : PTHrP

4. Hypocalcemia : osteoblastic metastases (prostate) : calcium consumption

5. Hypoglycemia : hepatocellular carcinoma, fibrosarcoma, mesothelioma : IGF2

6. Polycythemia : renal cell carcinoma, hepatocellular carcinoma, cerebellar hemangioblastoma, uterine leiomyoma : erythropoietin

7. Carcinoid syndrome (flushing, diarrhea, right sided valve disease) : carcinoid with liver metastases or bronchial carcinoid : serotonin

Neurologic

8. Lambert Eaton myasthenic syndrome : small cell lung carcinoma : anti P/Q type voltage gated calcium channel antibody

9. Myasthenia gravis : thymoma : anti acetylcholine receptor antibody

10. Subacute cerebellar degeneration : ovarian, breast, small cell lung : anti Yo, anti Hu, anti Tr

11. Limbic encephalitis : small cell lung : anti Hu

12. Opsoclonus myoclonus (dancing eyes, dancing feet) : neuroblastoma in children, small cell lung in adults

13. Anti NMDA receptor encephalitis : ovarian teratoma

Hematologic

14. Migratory thrombophlebitis (Trousseau sign) : pancreatic, lung, gastric adenocarcinoma : mucin and tissue factor

15. Nonbacterial thrombotic (marantic) endocarditis : mucinous adenocarcinoma

16. Disseminated intravascular coagulation : acute promyelocytic leukemia, adenocarcinoma

17. Eosinophilia : Hodgkin lymphoma, mycosis fungoides : IL5

Dermatologic

18. Acanthosis nigricans : gastric adenocarcinoma : TGF alpha

19. Seborrheic keratoses erupting suddenly (Leser Trelat sign) : gastric and other GI adenocarcinoma

20. Dermatomyositis (heliotrope rash, Gottron papules) : ovarian, lung, gastric

21. Sweet syndrome (acute febrile neutrophilic dermatosis) : acute myeloid leukemia

22. Pemphigus (paraneoplastic) : non Hodgkin lymphoma, CLL, Castleman disease

23. Necrolytic migratory erythema : glucagonoma

Musculosceletal and renal

24. Hypertrophic osteoarthropathy with clubbing : lung adenocarcinoma (not small cell)

25. Membranous nephropathy : solid tumors, especially lung and colon

26. Minimal change disease : Hodgkin lymphoma

27. Amyloidosis (AL type) : multiple myeloma, plasma cell dyscrasia

Paraneoplastic means the tumor is speaking through a molecule. Name the molecule and the tumor follows automatically.

Tumor follows… my friend.”

Stay updated with Hemostasis Today.

Acanthosis nigricans ACTH Acute Promyelocytic Leukemia Adenocarcinoma ADH Amyloidosis Blood Calcium Carcinoid syndrome Cushing syndrome Dermatomyositis Disseminated Intravascular Coagulation Eosinophilia Erythropoietin glucagonoma Health Hematology Hemostasis Hemostasis News Hemostasis Today Hodgkin lymphoma Hypercalcemia Hypertrophic osteoarthropathy hypocalcemia Hypoglycemia IGF2 IL5 Kamlesh Darji Lambert Eaton myasthenic syndrome Limbic encephalitis Medicine Membranous Nephropathy Migratory thrombophlebitis myasthenia gravis Necrolytic migratory erythema NMDA Nonbacterial thrombotic endocarditis Opsoclonus myoclonus Paraneoplastic Syndromes Pemphigus POLYCYTHEMIA PTHrP SIADH Subacute cerebellar degeneration Sweet syndrome Trousseau sign
NewsFeed