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Aug 30, 2026, 12:51
When to Escalate Treatment in Sickle Cell Crisis – ISBT
International Society of Blood Transfusion (ISBT) shared a post on LinkedIn:
“Sickle Cell Crisis: When to Escalate Therapy – Part 2
In part 1, we looked at the clinical red flags that can signal a complicated or organ-threatening sickling crisis. In part 2, we explore when red cell exchange (RCE) should be considered and where PLEX may fit in severe, refractory disease.
Key messages:
- Know when urgent RCE may be indicated.
- Reduce HbS while avoiding hyperviscosity.
- PLEX is not routine first-line therapy.
- Escalate early and involve a multidisciplinary team when severe organ dysfunction persists.
The goal: interrupt sickling, reverse organ injury and prevent irreversible damage.
Stay connected with the ISBT Clinical Transfusion Working Party for more educational content and updates in clinical transfusion.”
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